Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents
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概要
- 論文の詳細を見る
Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.
- 社団法人 日本農芸化学会の論文
- 2010-01-23
著者
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Kato Norihisa
Graduate School Of Biosphere Sci. Hiroshima Univ.
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YANAKA Noriyuki
Graduate School of Biosphere Science, Hiroshima University
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DAIRAKU Issei
Graduate School of Biosphere Science, Hiroshima University
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HAN Yunkyung
Graduate School of Biosphere Science, Hiroshima University
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Han Yunkyung
Graduate School Of Biosphere Science Hiroshima University
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Yanaka Noriyuki
Graduate School Of Biosphere Science Hiroshima University
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Dairaku Issei
Graduate School Of Biosphere Science Hiroshima University
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