Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice

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概要

• 論文の詳細を見る

• Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

• 社団法人 日本農芸化学会の論文
• 2005-01-23

著者

• Kato Norihisa

  Graduate School Of Biosphere Sci. Hiroshima Univ.

• Kato Norihisa

  Graduate School Of Biosphere Science Hiroshima University

• Chen Dong

  Graduate School Of Biosphere Science Hiroshima University

• HASHIMOTO Takao

  Graduate School of Biosphere Science, Hiroshima University

• FUKUNARI Atsushi

  Graduate School of Biosphere Science, Hiroshima University

• YAMADA Ichimaro

  Graduate School of Biosphere Science, Hiroshima University

• YANAKA Noriyuki

  Graduate School of Biosphere Science, Hiroshima University

• Yanaka Noriyuki

  Graduate School Of Biosphere Science Hiroshima University

• Fukunari A

  Graduate School Of Biosphere Science Hiroshima University

• Yamada Ichimaro

  Graduate School Of Biosphere Science Hiroshima University

• Hashimoto Takao

  Graduate School Of Biosphere Science Hiroshima University

関連論文

• Consumption of Pork-Liver Protein Hydrolysate Reduces Body Fat in Otsuka Long-Evans Tokushima Fatty Rats by Suppressing Hepatic Lipogenesis
• Y-700, a Novel Inhibitor of Xanthine Oxidase, Suppresses the Development of Colon Aberrant Crypt Foci and Cell Proliferation in 1,2-Dimethylhydrazine-Treated Mice
• Consumption of Curcumin Elevates Fecal Immunoglobulin A, an Index of Intestinal Immune Function, in Rats Fed a High-Fat Diet
• Supplementing Vitamin B_6 to a Low Vitamin B_6 Diet Exaggerates UVB-Induced Skin Tumorigenesis in DMBA-Treated Hairless Mice
• Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose Tolerance and Elevates Serum Adinonectin in Rats Fed a High-Fat Diet
• Inhibitory Effect of Curcumin on IMP Dehydrogenase, the Target for Anticancer and Antiviral Chemotherapy Agents
• Consumption of Sericin Suppresses Colon Oxidative Stress and Aberrant Crypt Foci in 1,2-Dimethylhydrazine-Treated Rats by Colon Undigested Sericin
• Consumption of Vitamin B6 Reduces Fecal Ratio of Lithocholic Acid to Deoxycholic Acid, a Risk Factor for Colon Cancer, in Rats Fed a High-Fat Diet
• Comparative Study on the Responses of Concentrations of B₆,-Vitamers in Several Tissues of Mice to Dietary Level of Pyridoxine

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