Validity of Diabetes Self-Reports in the Saku Diabetes Study

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概要

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• Background: Diabetes is an important risk factor for cardiovascular disease, certain types of cancer, and death, and self-reports are one of the most convenient methods for ascertaining diabetes status. We evaluated the validity of diabetes self-reports among Japanese who participated in a health checkup.<BR>Methods: Self-reported diabetes was cross-sectionally compared with confirmed diabetes among 2535 participants aged 28 to 85 years in the Saku cohort study. Confirmed diabetes was defined as the presence of at least 1 of the following: fasting plasma glucose (FPG) level of 126 mg/dL or higher, 2-hour post-load glucose (2-hPG) level of 200 mg/dL or higher after a 75-gram oral glucose tolerance test, glycated hemoglobin (HbA1c) level of 6.5% or higher, or treatment with hypoglycemic medication(s).<BR>Results: Of the 251 participants with self-reported diabetes, 121 were taking hypoglycemic medication(s) and an additional 69 were classified as having diabetes. Of the 2284 participants who did not self-report diabetes, 80 were classified as having diabetes. These data yielded a sensitivity of 70.4%, a specificity of 97.3%, a positive predictive value of 75.7%, and a negative predictive value of 96.5%. The frequency of participants with undiagnosed diabetes was 3.0%. Of these, 64.2% had FPG within the normal range and were diagnosed by 2-hPG and/or HbA1c.<BR>Conclusions: Our findings provide additional support for the use of self-reported diabetes as a measure of diabetes in epidemiologic studies performed in similar settings in Japan if biomarker-based diagnosis is difficult.

著者

• TERAUCHI YASUO

  Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine

• KATO Masayuki

  Japan Foundation for the Promotion of International Medical Research Cooperation

• Goto Maki

  Department Of Dermatology Hokkaido University Graduate School Of Medicine

• Terauchi Yasuo

  Department Of Endocrinology And Metabolism Graduate School Of Medicine Yokohama City University

• Miyachi Motohiko

  National Institute of Health and Nutrition

• WATANABE Shaw

  National Cancer Center Research Institute

• Goto Atsushi

  Department Of Diabetes And Metabolic Medicine International Medical Center Of Japan

• MORITA Akemi

  National Institute of Health and Nutrition

• Aiba Naomi

  Department Of Applied Nutrition National Institute Of Health And Nutrition

• Noda Mitsuhiko

  Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine

• Sasaki Satoshi

  Department Of Applied Physics Faculty Of Engineering Nagoya University

• SASAKI Satoshi

  Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo

• Goto Atsushi

  Department of Diabetes Research, Diabetes Research Center, National Center for Global Health and Medicine

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