Time-course of Changes of Visceral Fat Area, Liver Volume and Liver Fat Area during Intragastric Balloon Therapy in Japanese Super-obese Patients

スポンサーリンク

概要

• 論文の詳細を見る

• Objective The aim of this study was to assess the changes in the clinical parameters during intragastric balloon therapy for Japanese obese patients. Methods Between March 2009 and September 2010, 8 patients underwent intragastric balloon therapy at our hospital. The visceral fat area, liver volume and the liver-spleen ratio were measured by computed tomography. Blood examination and computerized tomography were performed before the balloon placement, and at 1, 3 and 6 months after the balloon placement in all of the patients. Results Eight patients (5 males and 3 females, median age, 39 years; median BMI, 44.0 kg/m2) underwent intragastric balloon therapy without severe complications. The median weight loss was 8.6 kg, mean BMI loss was 2.8 kg/m2, and the percent excess weight loss was 14.8% at 6 months after the balloon placement. The body weight and liver volume decreased significantly during the first month, and the results were maintained at the same levels until after the second month. The liver-spleen ratio also improved significantly during the first month, but worsened again during the last 3 months. The visceral fat area showed no significant differences during the treatment as well as no differences in liver enzymes, glucose and lipid metabolism. Conclusion Intragastric balloon therapy achieved a moderate effect in weight and liver volume reduction during the early months of the treatment. Intragastric balloon therapy may have a role as a minimally invasive method for pretreatment before laparoscopic surgery.

著者

• Endo Hiroki

  Gastroenterology Division, Yokohama City University School of Medicine

• Hosono Kunihiro

  Gastroenterology Division, Yokohama City University School of Medicine

• Sakamoto Yasunari

  Gastroenterology Division, Yokohama City University School of Medicine

• Koide Tomoko

  Gastroenterology Division, Yokohama City University School of Medicine

• Tokoro Chikako

  Gastroenterology Division, Yokohama City University School of Medicine

• Abe Yasunobu

  Gastroenterology Division Yokohama City University Graduate School Of Medicine

• Fujita Koji

  Gastroenterology Division, Yokohama City University School of Medicine

• Terauchi Yasuo

  Department Of Endocrinology And Metabolism Graduate School Of Medicine Yokohama City University

• Sekino Yusuke

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Takihata Masahiro

  Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Japan

• Gotoh Eiji

  Department Of Agriculture Kyushu University

• Iida Hiroshi

  Gastroenterology Division Yokohama City University Graduate School Of Medicine

• UCHIYAMA TAKASHI

  Gastroenterology Division, Yokohama City University Hospital

• SAKAI Eiji

  Gastroenterology Division, School of Medicine, Yokohama City University

• Saito Satoru

  Gastroenterological Center Yokohama City University Medical Center

• Nakajima Atsushi

  Gastroenterology Division Yokohama City University Hospital

• Maeda Shin

  Gastroenterology Division Yokohama City University Hospital

• Yoneda Masato

  Gastroenterology Division Yokohama City University School Of Medicine

• Inamori Masahiko

  Gastroenterology Division, Yokohama City University

• Yoneda Masato

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Takahashi Hirokazu

  Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan

• Takahashi Hirokazu

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Imajo Kento

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Sakamoto Yasunari

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Abe Yasunobu

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Hosono Kunihiro

  Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan

• Hosono Kunihiro

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Endo Hiroki

  Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan

• Endo Hiroki

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Terauchi Yasuo

  Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Japan

• Koide Tomoko

  Gastroenterology Division, Yokohama City University Graduate School of Medicine, Japan

• Tokoro Chikako

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

• Uchiyama Takashi

  Gastroenterology Division, Yokohama City University School of Medicine, Japan

関連論文

• A Novel Initial Codon Mutation of the Thiazide-sensitive Na-Cl Cotransporter Gene in a Japanese Patient with Gitelman's Syndrome
• Characteristics of small bowel injury in symptomatic chronic low-dose aspirin users : the experience of two medical centers in capsule endoscopy
• Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility
• Molecular Mechanism of Moderate Insulin Resistance in Adiponectin-Knockout Mice
• Chloroplast biogenesis during the early stage of leaf development in rice
• Impact of Increased PPARγ Activity in Adipocytes in vivo on Adiposity, Insulin Sensitivity and the Effects of Rosiglitazone Treatment
• Dissecting Intramural Hematoma of the Esophagus in a Kendo Player Taking Low-Dose Aspirin
• Gene expression profiling of non-alcoholic steatohepatitis using gene set enrichment analysis
• Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)
• Life Style-Related Diseases of the Digestive System : Colorectal Cancer as a Life Style-Related Disease : from Carcinogenesis to Medical Treatment
• Intravascular Lymphoma: Usefulness of Liver Biopsy in the Clinical Setting
• Lupus Enteritis Detected by Capsule Endoscopy
• PJ-296 Heterozygous PPAR γ Deficient Mice Showed Increased Neointima Formation with Vascular Smooth Muscle Cell Proliferation in Response to Cuff Injury(Atherosclerosis, Basic 3 (IHD) : PJ50)(Poster Session (Japanese))
• Lack of Insulin Receptor Substrate-2 Is a Link between Insulin Resistance and an Increased Intima of the Vessel in Mice
• Effectiveness of Repeated Intragastric Balloon Therapy in a Morbidly Obese Japanese Patient
• Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage
• Dose-response Trial of Lactoferrin in Patients with Chronic Hepatitis C
• Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer
• Outcome of transarterial chemoembolization monotherapy, and in combination with percutaneous ethanol injection, or radiofrequency ablation therapy for hepatocellular carcinoma
• Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population
• Diminished Left Ventricular Function and Coronary Perivascular Fibrosis Associated with Insulin Resistance do not Require Insulin Receptor Substarte-1 Mediated Signaling
• Effect of Dehydroepiandrosterone on Atherosclerosis in Apolipoprotein E-Deficient Mice
• A PROPOSAL FOR DIFFERENTIATION BETWEEN EARLY- AND ADVANCED-STAGE AUTOIMMUNE PANCREATITIS BY ENDOSCOPIC ULTRASONOGRAPHY
• Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms
• Clinical significance of the duodenal papilla in patients with separate orifices for the bile and pancreatic ducts
• Undifferentiated spindle-cell carcinoma of the gallbladder : an immunohistochemical study
• Blastocystis hominis infection in patient with regular dialysis
• Early effects of lafutidine or rabeprazole on intragastric acidity : which drug is more suitable for on-demand use?
• Evaluation of the effects of anti-secretory drugs on intragastric acidity : is combined therapy with a proton pump inhibitor and an H_2 receptor antagonist effective as initial treatment?
• The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH
• Lifestyle-Related Diseases of the Digestive System : A New In Vitro Model of Hepatitis C Virion Production : Application of Basic Research on Hepatitis C Virus to Clinical Medicine
• Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties
• Comparison of Adverse Gastrointestinal Effects of Acarbose and Miglitol in Healthy Men: A Crossover Study
• Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
• Influence of Pitavastatin on Glucose Tolerance in Patients with Type 2 Diabetes Mellitus
• Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity
• OE-220 Induction of Adipose PAI-1 Independent of Insulin Receptor Substrate-1 is the Major Determinant of Hypofibrinolysis in Insulin Resistance(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversar
• OE-119 Identification of Insulin Receptor Substrate Family Proteins Mediating PAI-1 Production in Cardiac and Adipose Tissues From IRS-1 Null Mice(Diabetes/Obesity/Metabolic syndrome-1 (H) OE20,Oral Presentation (English),The 70th Anniversary Annual Scien
• Induction of Adipose PAI-1 by Hyperinsulinemia in Vivo is the Major Determinant of Hypofibrinolysis in Obesity and Doesn't Require IRS-1(Thrombosis/Thrombolysis 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Genetically engineered models for type 2 diabetes
• Significant Association of Serum Albumin with Severity of Retinopathy and Neuropathy, in Addition to That of Nephropathy, in Japanese Type 2 Diabetic Patients
• Antibody-mediated Insulin Resistance Treated by Cessation of Insulin Administration
• Comparative Study of Effectiveness of Multiple-Daily Injections of Insulin Versus Twice-Daily Injections of Biphasic Insulin in Patients with Type 2 Diabetes
• Measurement of spleen volume is useful for distinguishing between simple steatosis and early-stage non-alcoholic steatohepatitis
• Clinical classification of congenital extrahepatic portosystemic shunts
• OE-318 Maintenance of Cardiac and Adipose PAI-1 Expression Despite the Lack of IRS-1 : a Knockout Mouse Study(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
• Selective Ablation of IRS-1 Decreases Cardiac Contractility without Attenuating PAI-1 Expression or Perivascular Fibrosis
• Divided-Dose Administration of Miglitol just before and 15 Minutes after the Start of a Meal Smoothes Postprandial Plasma Glucose Excursions and Serum Insulin Responses in Healthy Men
• Development and Progression of Retinopathy after Inpatient Management of Diabetes
• Pharmacology and new perspectives of angiotensin II receptor blocker in prostate cancer treatment
• Life Style-Related Diseases of the Digestive System : Endocrine Disruptors Stimulate Lipid Accumulation in Target Cells Related to Metabolic Syndrome
• Insights into Molecular Pathogenesis of Type 2 Diabetes from Knockout Mouse Models
• Influence of inducible nitric oxide synthase polymorphisms in Japanese patients with non-alcoholic fatty liver disease
• Evaluation of hepatocellular carcinoma with portal vein tumor thrombosis by CEUS before and after hepatic arterial infusion chemotherapy
• -489- ROLE OF THE HYPOTHALAMUS IN THE REGULATION OF RENIN SECRETION
• Safety of Fettweis squatting position in congenital dislocation of the hip : Experimental study of prevention of deformity of the femoral head and neck in pigs
• Life Style-Related Diseases of the Digestive System : from Molecular Mechanisms to Therapeutic Strategies : Preface
• Behçets Disease and Colon Cancer
• Factors predictive of relapse and spontaneous remission of autoimmune pancreatitis patients treated/not treated with corticosteroids
• HEMOLYTIC EPISODE FOLLOWING AN UPPER GASTROINTESTINAL ENDOSCOPY IN A PATIENT WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
• QUANTITATIVE ANALYSIS OF LOW-DOSE ASPIRIN-ASSOCIATED SMALL BOWEL INJURY USING A CAPSULE ENDOSCOPY SCORING INDEX
• DISCRIMINATION BETWEEN SCLEROSING CHOLANGITIS-ASSOCIATED AUTOIMMUNE PANCREATITIS AND PRIMARY SCLEROSING CHOLANGITIS, CANCER USING INTRADUCTAL ULTRASONOGRAPHY
• RISKY ENDOSCOPIC ULTRASONOGRAPHY-GUIDED FINE-NEEDLE ASPIRATION FOR ASYMPTOMATIC RETROPERITONEAL TUMORS
• Complications of the treatment of endoscopic biliary strictures developing after liver transplantation
• Time-course of Changes of Visceral Fat Area, Liver Volume and Liver Fat Area during Intragastric Balloon Therapy in Japanese Super-obese Patients
• Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users : a pilot randomized controlled study
• Leptin receptor is involved in STAT3 activation in human colorectal adenoma
• Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)
• Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia
• Correlations of Fasting and Postprandial Blood Glucose Increments to the Overall Diurnal Hyperglycemic Status in Type 2 Diabetic Patients : Variations with Levels of HbA1c
• Present status of sulfonylurea treatment for type 2 diabetes in Japan : second report of a cross-sectional survey of 15,652 patients
• Decreased Insulin Secretion and Accumulation of Triglyceride in β Cells Overexpressing a Dominant-negative Form of AMP-activated Protein Kinase
• Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide levels in healthy men
• Novel Findings for the Development of Drug Therapy for Various Liver Diseases : Liver Microsomal Triglyceride Transfer Protein Activator May Be a Possible Therapeutic Agent in Non-alcoholic Steatohepatitis
• Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests
• A Case of Rectal Cancer Arising from Long-Standing Prolapsed Mucosa of the Rectum
• Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer
• Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence
• Evaluation of organ-specific glucose metabolism by ^F-FDG in insulin receptor substrate-1 (IRS-1) knockout mice as a model of insulin resistance
• Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men
• Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance (the J-PREDICT study) : rationale, study design, and clinical characteristics of 1269 patients
• Effect of Acarbose Therapy Once or Twice a Day on Glycemic Control in Japanese Patients with Type 2 Diabetes
• Imaging Findings of Pancreatic Cystic Lesions in von Hippel-Lindau Disease
• Which is the best method to estimate the actual ureteral length in patients undergoing ureteral stent placement?
• Comparison of plasma active glucagon-like peptide-1 (GLP-1) levels assayed with or without plasma extraction in non-diabetic men
• Validity of Diabetes Self-Reports in the Saku Diabetes Study
• Gastric Neuroendocrine Carcinoma with Non-islet Cell Tumor Hypoglycemia Associated with Enhanced Production of Insulin-like Growth Factor II
• Hepatic Portal Venous Gas Development Following Percutaneous Endoscopic Gastrostomy
• Life Style-Related Diseases of the Digestive System: Colorectal Cancer as a Life Style-Related Disease: from Carcinogenesis to Medical Treatment
• Life Style-Related Disease and Colorectal Cancer
• Feasibility and Validity of a Computer-based Version of SEIQoL-DW Compared to Original Interview-based Versions in Healthy Medical Students
• Relationship between Coronary Artery Disease and Retinopathy in Patients with Type 2 Diabetes Mellitus
• Pituitary Abscess with Panhypopituitarism Showing T1 Signal Hyperintensity of the Marginal Pituitary Area: A Non-invasive Differential Diagnosis of Pituitary Abscess and Pituitary Apoplexy
• Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy
• Factors associated with the glucose-lowering effect of vildagliptin identified from the results of the oral glucose tolerance test in Japanese patients with type 2 diabetes
• Mosapride citrate, a 5-HT_4 receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men

もっと見る 閉じる

スポンサーリンク