Gastric Neuroendocrine Carcinoma with Non-islet Cell Tumor Hypoglycemia Associated with Enhanced Production of Insulin-like Growth Factor II
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概要
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A 75-year-old man was admitted to the hospital with a loss of consciousness. His blood glucose level was 24 mg/dL. Abdominal computed tomography revealed multiple metastatic lesions in the liver, while upper endoscopy disclosed advanced gastric cancer. The hypoglycemia was refractory despite the administration of glucose and steroid therapy. The patient died within one month of admission. An autopsy revealed neuroendocrine-type gastric cancer, which, on examination with immunohistochemistry, was found to be negative for insulin and insulin-like growth factor I and positive for insulin-like growth factor II (IGF-II). The patient was diagnosed as having gastric cancer with non-islet cell tumor hypoglycemia (NICTH) caused by IGF-II.
著者
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Sakamoto Atsuhiko
Department Of Orthopaedic Surgery Nihon University School Of Medicine
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Ida Tomonori
Department Of Chemistry Faculty Of Science Kanazawa University
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Ohara Hiroshi
Department Of Clinical Pharmacy Tohoku University Graduate School Of Pharmaceutical Sciences
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Nakajima Atsushi
Gastroenterology Division Yokohama City University Hospital
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Ishikawa Yukio
Department Of Clinical Laboratory Sado General Hospital
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Maeda Shin
Gastroenterology Division Yokohama City University Hospital
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Inamori Masahiko
Gastroenterology Division, Yokohama City University
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Goto Toru
Department of Gastroenterology, Omori Red Cross Hospital, Japan
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Morohashi Taiki
Department of Gastroenterology, Omori Red Cross Hospital, Japan
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Tsukumo Yoko
Department of Pathology, Omori Red Cross Hospital, Japan
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Nakajima Atsushi
Gastroenterology Division, Yokohama City University Hospital, Japan
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