Use of Insulin Glargine in Japanese Patients with Type 1 Diabetes
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概要
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Objective To evaluate the results of treatment with an insulin glargine-based regimen as compared with those of an NPH insulin-based regimen. Methods We reviewed the charts of 83 Japanese patients with Type 1 diabetes treated with insulin glargine for 12 months. Patients Median age, 56.9 years (range, 24.6-74.8 years), mean (±S.D.) body mass index, 21.2 (±2.2) kg/m2. Results The average HbA1c level of the cohort was 7.8 ± 1.2% at baseline and 7.7 ± 1.0% at the end of the 12-month treatment (P=0.34). The average insulin requirement per day in the cohort remained unchanged after the 12-month treatment (35.0 ± 11.6 units/day versus 35.2 ± 11.2 units/day (P=0.58). Of the 36 patients who were receiving twice or three times daily injections of NPH insulin, 30 could be switched to a single-daily injection of insulin glargine. The frequency of severe hypoglycemia with unconsciousness became lower after switching to the insulin glargine-based regimen than during treatment with the NPH-based regimen. The average ratio of the daily usage of insulin glargine to that of total insulin after 12 months was smaller than that reported from other countries (0.34 ± 0.09). Conclusion These results obtained from a larger number of patients as compared to previous Japanese studies confirm earlier reports that insulin glargine provides equivalent glycemic control to human NPH insulin, with a lower incidence of severe hypoglycemia. Thus, treatment with insulin glargine provides some benefits to Japanese patients with Type 1 diabetes.
著者
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Akanuma Yasuo
Department Of Endocrinology And Metabolism Marunouchi Hospital Attached To The Institute For Adult D
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Yoshida Yoko
Department Dermatology Faculty Of Medicine Kyoto University
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Hara Yoko
Department Of Obstetrics And Gynecology Hokkaido University Graduate School Of Medicine
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Kikuchi Masatoshi
Department Of Medicine (ii) Niigata University School Of Medicine
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Kajio Hiroshi
Department Of Cardiovascular Medicine Heart Failure Division National Cerebral And Cardiovascular Ce
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Tanaka Takahisa
Department Of Diabetes And Metabolic Medicine National Center For Global Health And Medicine
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Kitazato Hiroji
Department Of Diabetes And Endocrinology Oomori Red Cross Hospital
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Yamamoto-honda Ritsuko
Department Of Diabetes And Metabolic Medicine National Center For Global Health And Medicine
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Noda Mitsuhiko
Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine
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TAKAHASHI YOSHIHIKO
Department of Anatomy Kurume, University School of Medicine
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Noda Mitsuhiko
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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Kawai Atsuo
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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Hara Yoko
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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Akanuma Yasuo
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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Yamamoto-Honda Ritsuko
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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Kikuchi Masatoshi
Department of Endocrinology and Metabolism, Marunouchi Hospital attached to the Institute for Adult Diseases, Asahi Life Fondation
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