Hemoglobin Variant HbE Found in Two South Asian Diabetic Patients
スポンサーリンク
概要
- 論文の詳細を見る
Glycohemoglobin, also known as hemoglobin (Hb) A1c, is a marker of long-term glycemic control in patients with diabetes. We present two South-Asian diabetic patients whose HbA1c peaks were not measurable using high performance liquid chromatography (HPLC). Further investigations showed that these patients were homozygous for a hemoglobin variant, HbE (β26 Glu→Lys). Because of the increasing numbers of immigrants in Japan, area-specific hemoglobinopathies are now encountered more frequently than before. Thus, if discrepant results are found on an HbA1c assay or if the HbA1c value cannot be measured, such patients should be screened for hemoglobinopathies and alternative measurements for monitoring diabetes should be considered.
- 社団法人 日本内科学会の論文
著者
-
Harano Keiko
Department Of Biochemistry Kawasaki Medical School
-
Kajio Hiroshi
Department Of Cardiovascular Medicine Heart Failure Division National Cerebral And Cardiovascular Ce
-
Kishimoto Miyako
Department Of Diabetes And Metabolic Medicine International Medical Center Of Japan
-
Tanaka Takahisa
Department Of Diabetes And Metabolic Medicine National Center For Global Health And Medicine
-
Noda Mitsuhiko
Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine
-
TAKAHASHI YOSHIHIKO
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital
-
TAKAHASHI YOSHIHIKO
Department of Anatomy Kurume, University School of Medicine
-
Noda Mitsuhiko
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital
-
Takarabe Daisuke
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital
-
HARANO Keiko
Department of Biochemistry and Department of Clinical Pathology, Kawasaki Medical School
-
Kajio Hiroshi
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital
-
Tanaka Takahisa
Department of Diabetes and Metabolic Medicine, International Medical Center of Japan, Toyama Hospital
関連論文
- Fasting Plasma Glucose and Incidence of Diabetes---Implication for the Threshold for Impaired Fasting Glucose : Results from the Population-Based Omiya MA Cohort Study
- Basaloid squamous-cell carcinoma of the lung in a young woman
- Aspirin Oral Ointment for the Remedy of Oral Mucosal Diseases
- Distribution of Blood Glucose and the Correlation between Blood Glucose and Hemoglobin A1c Levels in Diabetic Outpatients
- Psychological Factors, Coffee and Risk of Diabetes Mellitus among Middle-Aged Japanese : a Population-Based Prospective Study in the JPHC Study Cohort
- Pineal malignant rhabdoid tumor with chondroid formation in an adult
- Postoperative Chronic Subdural Hematoma Following Craniotomy : Four Case Reports
- Band 4.2 Komatsu: 523 GAT → TAT (175 Asp → Tyr) in exon 4 of the band 4.2 gane associated with total deficiency of band 4.2, hemolytic anemia with ovalostomatocytosis and marked disruption of the cytoskeletal network
- Detection and Differentiation of Malaria Parasites in DNA Extracted from Blood Samples by the Polymerase Chain Reaction (PCR)
- Molecular Aspects of α-Thalassemia in Myanmar
- Aberrant mRNA Spliced in a β^0-Thalassemic Gene Having a G→A Mutation at βIVS II-1
- Molecular Aspects of Transfusion Dependent Thalassemic Children in Myanmar : Analysis of Common β-Thalassemia in Myanmar by Amplification Refractory Mutation System (ARMS)
- Adult Onset, Chronic Anemias of Undermined Etiology, Myanmar
- Prevalence of Hemoglobin E Among the Children Taking Regular Blood Transfusion at the Day Care Room, Yangon Children Hospital, Myanmar
- An Insight into Heterozygous β-Thalassemia, Myanmar
- Use of Insulin Glargine in Japanese Patients with Type 1 Diabetes
- An Elderly Case of Type 2 Diabetes which Developed in Association with Oral and Esophageal Candidiasis
- Rapid-Onset Type 1 Diabetes Associated with Cytomegalovirus Infection and Islet Autoantibody Synthesis
- Hb Nishinomiya [Leu-Gly-Inserted between Codons 69 (E13) and 70 (E14) of β] : A Novel Unstable Hemoglobin with Reduced Oxygen Affinity Found in a Patient with Spherocytic Hemolysis
- Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar
- An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia
- Malaria Parasites Detected in Myanmar Thalassemia Patients
- Hemoglobinopathies and Malaria Infection in Myanmar
- Cervical Myelopathy Due to Compression by Bilateral Vertebral Arteries
- A Rare Super-Unstable Hemoglobin Variant, Hb Monroe [β30(B12)Arg→Thr], Found in Two Myanmar Children
- A Case Report of Diagnosis of α-thalassemia-2
- A Case of Fulminant Type 1 Diabetes Associated With Significant Elevation of Mumps Titers
- Development of a Database of Health Insurance Claims : Standardization of Disease Classifications and Anonymous Record Linkage
- Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle
- Identification of a Rare Hemoglobin Variant, Hb Nagasaki [β17(A14)Lys→Glu], Found in a Japanese by the Techniques of Protein Chemistry and the DNA Analysis
- Determination of Hemoglobin A_ Content by an Automated Hemoglobin Analyzer, HLC-723G7, Myanmar
- Hemoglobin Pitie-Salpetriere [β34 (B16) Val→Phe] Showing Erythrocytosis and Mild Hemolysis in a Japanese Man
- A Study on Molecular Basis of Hypochromic Microcytic Anemia in Myanmar
- Application of an Automated Hemoglobin Analyzer, HLC-723G7, for Clinical Samples
- Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)
- Normal glucose tolerance with high HbA1c levels observed in two cases of Hb variants
- Validity and applicability of a simple questionnaire for the estimation of total and domain-specific physical activity
- Decreased Insulin Secretion and Accumulation of Triglyceride in β Cells Overexpressing a Dominant-negative Form of AMP-activated Protein Kinase
- Insulin secretion and insulin sensitivity in Japanese patients with type 2 diabetes : a cross-sectional study comparing the homeostasis model assessment-2 (HOMA2) indexes and indexes derived from the oral glucose tolerance test
- Body Mass Index, Fasting Plasma Glucose Levels, and C-peptide Levels as Predictors of the Future Insulin Use in Japanese Type 2 Diabetic Patients
- Primary Aldosteronism Associated with Severe Rhabdomyolysis Due to Profound Hypokalemia
- Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests
- Fasting plasma glucose and 5-year incidence of diabetes in the JPHC diabetes study-suggestion for the threshold for impaired fasting glucose among Japanese
- The PREDICTIVE Study : a multinational, prospective observational study to evaluate the safety and efficacy of insulin detemir treatment in patients with type 1 and 2 diabetes―data from the Japan cohort
- Japan Prevention Trial of Diabetes by Pitavastatin in Patients with Impaired Glucose Tolerance (the J-PREDICT study) : rationale, study design, and clinical characteristics of 1269 patients
- A Morbid Obese Japanese Woman with a Body Mass Index of 83.2 kg/m2: Before and after Sleeve Gastrectomy
- A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA_
- International clinical harmonization of glycated hemoglobin in Japan : From Japan Diabetes Society to National Glycohemoglobin Standardization Program values
- Validity of Diabetes Self-Reports in the Saku Diabetes Study
- Transient Global Amnesia and Dural Arteriovenous Fistula of the Anterior Cranial Fossa.
- Scanning Electron Microscopic Observations of the Arachnoid Granulations in Monkeys with Cerebrospinal Fluid Hypotension.
- Successful Treatment of Chronic Intractable Itching Using Oral Pregabalin in a Patient with Diabetes and Systemic Prurigo Nodularis: A Case Report of an Iliopsoas Muscle Abscess
- Hemoglobin Variant HbE Found in Two South Asian Diabetic Patients
- Improved method for quantiation of biosynthesized human globin chains in reticulocytes by use of urea cellulose acetate membrane electrophoresis.
- Ultrastructure of the Perineurial Cell of the Sciatic Nerve in Rats. A Transmission and Scanning Electron Microscopic Study.:A Transmission and Scanning Electron Microscopic Study
- Possible Aggravation and Recovery of Slowly Progressive Type 1 Diabetes by Onset and Resolution of Oral and Esophageal Candidiasis
- Hypopituitarism Caused by Bilateral Internal Carotid Artery Aneurysms with a Carotid-cavernous Fistula
- Clinicopathological Features of Intraorbital Neurinoma. Report of a Cace.:Report of Two Cases
- Delayed CSF Pseudocyst following Shunt Malfunction after Myelomeningocele Repair.
- Tolosa-Hunt Syndrome with Atypical Intrasellar and Juxtasellal Lesions. Two Case Reports.:Two Case Reports