Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar
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概要
- 論文の詳細を見る
We had the opportunity to study the members of 10 families with Hb E/β-thalassemia and characterized the ethnic features of the population of Myanmar from haplotyping of aβ-globin-like gene cluster producing Hb E. Detection of the Hb E andβ^E-globin genes was carried out by DEAE-HPLC and isoelectric focusing of the hemolysates, by electrophoresis of DNA fragments which resulted in the digestion of the PCR product with Mn/I, and by PCR-direct sequencing. The haplotype of the β-globin-like gene cluster was determined by the presence (+) or absence (-) of the restriction enzyme site in the PCR product including the polymorphic site. Polymorphism or the haplotype were determined at seven sites, 5' to the ε-gene/HincII, in the ^Gγ-gene/HindIII, in the ^Aγ-gene/HindIII, in the ψβ-gene/HincII, 3' to the ψβ-gene/HincII, in the β-IVS II/AvaII and 3' to the β-gene/BamHI, in the β-globin-like gene cluster. Three types of haplotypes were found in this study; (a) - + - + + + - (five families), (b) + - - - - + - (four families) and (c) + - - + + + - (one family). Haplotypes (a) and (b) were identified as one's in the Thai and Cambodian populations in eastern Myanmar. They were considered to be the most common haplotypes in that area and to have been the result of gene confusion or gene flow between ethnic groups. Haplotype (c), on the other hand, was a rare type, suggesting both the specificity and diversity of ethnic groups in Myanmar.
- 川崎医科大学の論文
著者
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Hodohara Keiko
Department Of Medicine Shiga University Of Medical Science
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HARANO Teruo
Department of Biochemistry, Kawasaki Medical School
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HARANO Keiko
Department of Clinical Nutrition, Faculty of Medical Professions, Kawasaki University of Medical Wel
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Hodohara Keiko
Department Of Hematology Of Shiga University Of Medical Science
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Tin Yi
Department Of Biochemistry Kawasaki Medical School
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Harano K
Department Of Clinical Nutrition Faculty Of Medical Professions Kawasaki University Of Medical Welfa
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Harano Keiko
Department Of Biochemistry Kawasaki Medical School
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Harano T
Department Of Biochemistry Kawasaki Medical School
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Harano Teruo
Department Of Biochemistry Kawasaki Medical School
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HARANO Keiko
Department of Biochemistry and Department of Clinical Pathology, Kawasaki Medical School
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HARANO Teruo
Department of Biochemistry and Department of Clinical Pathology, Kawasaki Medical School
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