An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the usefulness of an automated analyzer, the HLC-723G7, for determination of Hb A2 in the diagnosis of β-thalassemia. The analyzer was used for 250 Thai subjects who were either normal or were diagnosed with microcytic hypochromia based on hematological findings. An intra-assay precision test of normal subject (Hb A_2 = 2.78%) and that (Hb A_2 = 5.90%) with β-thalassemia revealed as coefficients of variation (CV%) of 3.2% and 0.95%, respectively. Samples were kept stable at 4℃ for at least 10 days. The Hb A_2 values obtained by the HLC-723G7 showed good correlation with those obtained by DEAE-HPLC with the coefficient of correlation (r) being 0.940, the coefficient of determination (R^2) 0.884, and the equation of the regression line Y_<G7> = 1.057X_<DEAE>-0.248. The subjects with a higher Hb A_2 value than about 4% were suspected of having β-thalassemia based on hematological findings. Most of those with a lower or relatively lower Hb A_2 value than the normal range (2.3-3.5%) or 4% and hematological abnormalities were considered to be suffering from α-thalassemia-1, α-thalassemia-2 or iron deficiency anemia. However, a confirmed diagnosis must be made by the further study of the red cell morphology, clinical manifestations and by the DNA analysis.
- 川崎医科大学の論文
著者
-
Hodohara Keiko
Department Of Medicine Shiga University Of Medical Science
-
HARANO Teruo
Department of Biochemistry, Kawasaki Medical School
-
SUETSUGU Yoshimasa
Division of Hematology, Department of Medicine, Kawasaki Medical School
-
HARANO Keiko
Department of Clinical Nutrition, Faculty of Medical Professions, Kawasaki University of Medical Wel
-
SUETSUGU Yoshimasa
Department of Biochemistry, Kawasaki Medical School
-
Hodohara Keiko
Department Of Hematology Of Shiga University Of Medical Science
-
Tin Yi
Department Of Biochemistry Kawasaki Medical School
-
Harano K
Department Of Clinical Nutrition Faculty Of Medical Professions Kawasaki University Of Medical Welfa
-
Harano Keiko
Department Of Biochemistry Kawasaki Medical School
-
Harano T
Department Of Biochemistry Kawasaki Medical School
-
Harano Teruo
Department Of Biochemistry Kawasaki Medical School
-
SUTCHARITCHAN Pranee
Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
-
SETTAPIBOON Rung
Division of Hematology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
-
Suetsugu Y
Division Of Hematology Department Of Medicine Kawasaki Medical School
-
Settapiboon Rung
Division Of Hematology Department Of Medicine Faculty Of Medicine Chulalongkorn University
-
Sutcharitchan Pranee
Division Of Hematology Department Of Medicine Faculty Of Medicine Chulalongkorn University
-
HARANO Keiko
Department of Biochemistry and Department of Clinical Pathology, Kawasaki Medical School
-
HARANO Teruo
Department of Biochemistry and Department of Clinical Pathology, Kawasaki Medical School
関連論文
- A Diabetic Case with Hemoglobin J-Meerut and Low HbA_ Levels
- Treatment of ulcerative colitis by feeding with germinated barley foodstuff : first report of a multicenter open control trial
- PYOGENIC GRANULOMA IN THE ILEUM
- Monocyte/Macrophage-Specific Marker CD163^+ Histiocytic Sarcoma : Case Report with Clinical, Morphologic, Immunohistochemical, and Molecular Genetic Studies
- Multiple Myeloma Complicated by Autoimmune Hemolytic Anemia
- The preventive factors for aspirin-induced peptic ulcer : aspirin ulcer and corpus atrophy
- Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin
- ECHINOSTOMA HORTENSE ASADA INFECTION IN THE DUODENUM : INCIDENTAL FINDINGS DURING ROUTINE GATROINTESTINAL ENDOSCOPY
- Clinical prevention of gastric cancer by Helicobacter pylori eradication therapy : a systematic review
- Relation between histologic gastritis and gastric motility in Japanese patients with functional dyspepsia : evaluation by transabdominal ultrasonography
- NODULAR GASTRITIS WITH HELICOBACTER PYLORI INFECTION IS STRONGLY ASSOCIATED WITH DIFFUSE-TYPE GASTRIC CANCER IN YOUNG PATIENTS
- Stepped assessment of gastric emptying of a solid meal using the ^C-octanoic acid breath test
- Acute lupus peritonitis successfully treated with steroid pulse therapy
- Thalassemia Incidentally Found by Marked Erythrocytosis Due to an Ochre Mutation at Codon 35 in a Japanese Man
- Fluctuation in Therapeutic Control Associated with Interchange of Prednisolone Tablet Formulations : Assessment of Bioequivalence by Dissolution Test
- Aggressive jejunal γ δT-cell lymphoma derived from intraepithelial lymphocytes: An autopsy case report
- Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency
- Band 4.2 Komatsu: 523 GAT → TAT (175 Asp → Tyr) in exon 4 of the band 4.2 gane associated with total deficiency of band 4.2, hemolytic anemia with ovalostomatocytosis and marked disruption of the cytoskeletal network
- Detection and Differentiation of Malaria Parasites in DNA Extracted from Blood Samples by the Polymerase Chain Reaction (PCR)
- Molecular Aspects of α-Thalassemia in Myanmar
- Aberrant mRNA Spliced in a β^0-Thalassemic Gene Having a G→A Mutation at βIVS II-1
- Molecular Aspects of Transfusion Dependent Thalassemic Children in Myanmar : Analysis of Common β-Thalassemia in Myanmar by Amplification Refractory Mutation System (ARMS)
- Adult Onset, Chronic Anemias of Undermined Etiology, Myanmar
- Prevalence of Hemoglobin E Among the Children Taking Regular Blood Transfusion at the Day Care Room, Yangon Children Hospital, Myanmar
- An Insight into Heterozygous β-Thalassemia, Myanmar
- Simple and non-invasive assessment of the accommodation reflex of the proximal stomach
- AUTOIMMUNE PANCREATITIS ASSOCIATED WITH ULCERATIVE COLITIS
- Increased aggregation response of platelets in patients with inflammatory bowel disease
- Application of 2-aminopyridine fluorescence labeling in the analysis of in vivo and in vitro metabolism of dextran sulfate sodium by size-exclusion high-performance liquid chromatography
- The Expression of Chemokine Genes Correlates with Nuclear Factor-κB Activation in Human Pancreatic Cancer Cell Lines
- Transforming Growth Factor-β1 Acts as a Potent Inhibitor of Complement C3 Biosynthesis in Human Pancreatic Cancer Cell Lines
- Regulation of complement C3 synthesis by interleukin-1 and transforming growth factor-β in rat non-transformed intestinal epithelial cell line, IEC-6
- Duodenal hypersensitivity to acid in patients with functional dyspepsia-pathogenesis and evaluation
- High-salt and high-fat diets promote corpus atrophic gastritis in Mongolian gerbils
- Real-time evaluation of dyspeptic symptoms and gastric motility induced by duodenal acidification using noninvasive transnasal endoscopy
- Low-dose aspirin-induced gastrointestinal diseases : past, present, and future
- Nodular gastritis in Japanese young adults : endoscopic and histological observations
- CAN DENTAL TREATMENT BE THE INFECTION ROUTE OF H. PYLORI TRANSMISSION IN ADULTS? THREE CASES OF ACUTE GASTRIC MUCOSAL LESIONS AFTER DENTAL TREATMENT
- Hb Nishinomiya [Leu-Gly-Inserted between Codons 69 (E13) and 70 (E14) of β] : A Novel Unstable Hemoglobin with Reduced Oxygen Affinity Found in a Patient with Spherocytic Hemolysis
- Ecabet sodium induces neuronal nitric oxide synthase-derived nitric oxide synthesis and gastric adaptive relaxation in the human stomach
- Haplotypes of the β^E-Globin Gene Cluster Found in Myanmar
- An Automated Hb A_2 Analyzer, HLC-723G7, for Diagnosis of β-Thalassemia
- Malaria Parasites Detected in Myanmar Thalassemia Patients
- Hemoglobinopathies and Malaria Infection in Myanmar
- A Rare Super-Unstable Hemoglobin Variant, Hb Monroe [β30(B12)Arg→Thr], Found in Two Myanmar Children
- A Case Report of Diagnosis of α-thalassemia-2
- MLL/AF-1p Fusion in Therapy-Related Early Pre-B Acute Lymphoblastic Leukemia with t(1;11)(p32;q23) Translocation Developing in the Relapse Phase of Acute Promyelocytic Leukemia
- Efficacy of mosapride citrate in proximal gastric accommodation and gastrointestinal motility in healthy volunteers : a double-blind placebo-controlled ultrasonographic study
- Identification of a Rare Hemoglobin Variant, Hb Nagasaki [β17(A14)Lys→Glu], Found in a Japanese by the Techniques of Protein Chemistry and the DNA Analysis
- Determination of Hemoglobin A_ Content by an Automated Hemoglobin Analyzer, HLC-723G7, Myanmar
- Hemoglobin Pitie-Salpetriere [β34 (B16) Val→Phe] Showing Erythrocytosis and Mild Hemolysis in a Japanese Man
- Evaluation of RAPID^【○!R】 5 Access software for examination of capsule endoscopies and reading of the capsule by an endoscopy nurse
- Clinical and hematological characteristics of uncommon beta-globin variants in Thailand
- DOES SHORT-SEGMENT COLUMNAR-LINED ESOPHAGUS ELONGATE DURING A MEAN FOLLOW-UP PERIOD OF 5.7 YEARS?
- A Study on Molecular Basis of Hypochromic Microcytic Anemia in Myanmar
- Application of an Automated Hemoglobin Analyzer, HLC-723G7, for Clinical Samples
- Normal glucose tolerance with high HbA1c levels observed in two cases of Hb variants
- A case of hemoglobin Hiroshima (β146 histidine to aspartic acid) with compensatory erythremia and undetectable HbA_
- Hemoglobin Variant HbE Found in Two South Asian Diabetic Patients
- Improved method for quantiation of biosynthesized human globin chains in reticulocytes by use of urea cellulose acetate membrane electrophoresis.
- The Total Synthesis of (±)-Isoelliptone
- Hemoglobin biosynthesis in reticulocytes of a patient with Hb M Hyde park (.BETA.92 His.RAR.Tyr) disease.