Rapid-Onset Type 1 Diabetes Associated with Cytomegalovirus Infection and Islet Autoantibody Synthesis
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概要
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We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1*0901-DQA1*03-DQB1*0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.
著者
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Yasuda Kazuki
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Kajio Hiroshi
Department Of Cardiovascular Medicine Heart Failure Division National Cerebral And Cardiovascular Ce
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Kishimoto Miyako
Department Of Diabetes And Metabolic Medicine International Medical Center Of Japan
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Osame Keiichiro
Department Of Diabetes And Metabolic Medicine National Center For Global Health And Medicine
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Noda Mitsuhiko
Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine
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Kaburagi Yasushi
Department Of Diabetic Complications Diabetes Research Center Research Institute National Center For Global Health And Medicine
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TAKAHASHI YOSHIHIKO
Department of Anatomy Kurume, University School of Medicine
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Noda Mitsuhiko
Department of Endocrinology and Metabolism, Toranomon Hospital
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Takasawa Hirofumi
Department of Endocrinology and Metabolism, Toranomon Hospital
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Kaburagi Yasushi
Department of Endocrinology and Metabolism, Toranomon Hospital
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Takasawa Hirofumi
Department of Endocrinology and Metabolism, International Medical Center of Japan
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Yasuda Kazuki
Department of Endocrinology and Metabolism, Toranomon Hospital
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Yasuda Kazuki
Department of Endocrinology and Metabolism, International Medical Center of Japan
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