Berberine Inhibits Hepatic Stellate Cell Proliferation and Prevents Experimental Liver Fibrosis
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概要
- 論文の詳細を見る
Proliferation of hepatic stellate cells (HSCs) is central for the development of fibrosis during liver injury. Our aim in this study was to determine whether berberine could inhibit HSC proliferation in vitro and prevent experimental liver fibrosis in vivo. Activated rat hepatic stellate cells (CFSCs) were incubated with various concentrations (0—20 μg/ml) of berberine. After 48 h incubation, berberine significantly inhibited CFSC proliferation and induced cell cycle arrest in G1 phase. Real-time and Western blotting revealed that both p21 and p27 expression was markedly reduced by berberine. Berberine also decreased Akt phosphorylation and FoxO1 phosphorylation, which led to FoxO1 nuclear translocation. Berberine effectively prevented CCl4-induced liver fibrosis in mice, which was accompanied by a decrease in the number of activated HSCs. Thus, berberine was able to prevent liver fibrosis by inhibition of hepatic stellate cell proliferation.
- 日本薬学会の論文
著者
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YASUDA Kazuki
Department of Metabolic Disorder, Research Institute, International Medical Center of Japan
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Chen Jie
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Sun Xu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Zhang Xiaodong
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Hu Hui
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Lu Yina
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Wang Heyao
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Wang Heyao
Shanghai Institute Of Materia Medica Chinese Academy Of Science
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Yasuda Kazuki
Department Of Internal Medicine And Molecular Science Graduate School Of Medicine Osaka University
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Zhang Xiaodong
Shanghai Institute Of Materia Medica Chinese Academy Of Science
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Yasuda Kazuki
Department of Endocrinology and Metabolism, International Medical Center of Japan
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