Dioxin exposure and type 2 diabetes mellitus: Case control study
スポンサーリンク
概要
- 論文の詳細を見る
OBJECTIVES: Relationship between dioxin exposure and diabetes mellitus (DM) has been in debate. Our cross-sectional study suggested that low-level dioxin exposure may cause type 2 diabetes in a general population. A case control study was performed to confirm the risk of dioxins. DESIGN and METHODS: 60 DM patients and 60 controls were selected for the case control study to detect the risk of dioxins for type 2 diabetes mellitus. After performing 75 g GTT, 56 DM, 12 IGT and 49 Control were grouped. In addition to the routine physical examination, questionnaire for life habits, past illness, family history and others were performed. 70 ml blood was collected for hematological and biochemical test, and measurement of 7 polychlorodibenzo-p-dioxins (PCDD), 10 polychloro-dibenzofurans (PCDF), and 12 coplanar polychlorobiphenyl (PCB). Concentration of dioxin congeners and their TEQ were used for regression factor analysis and logistic regression analysis to detect the risk of dioxins by SPSS. RESULTS: Total blood dioxin level was 23.4 ± 11.2 in Control, 30.8 ± 11.5 in IGT and 33.7 ± 13.7 pg TEQ/g lipid in DM. Logistic regression analysis revealed that family history (OR=20.4) and 4 of 5 dioxin factors (OR=2.2-2.8) had significant odds ratio. Crude congener concentration and their TEQ yielded the similar results. Other variables did not show significant odds ratio. Adverse effects of dioxins on TNFalpha, NEFA, adiponectin, and leptin were found. CONCLUSION: DM and IGT patients showed higher dioxin level compared to Control. Logistic regression analysis revealed that the exposure to both PCB and PCDD/PCDF showed significant effect.
著者
-
WATANABE Shaw
National Cancer Center Research Institute
-
HIRAI Tetsuya
Otsuka Pharmaceutical Co. Ltd.
-
MIZUNO Shoichi
National Institute of Health and Nutrition
-
Morioka Masahiro
Saku Central Hospital
関連論文
- Association of Personality (NEO-Five Factor Inventory) with Eating Behaviors and Physical Activity Levels in Obese Subjects in the Saku Control Obesity Program (SCOP)
- Study Design of the Saku Control Obesity Program (SCOP)
- Study Design and Organization of the JPHC Study
- Effects of Various Soap Elements on Skin
- Accuracy of Predictive Equations for Basal Metabolic Rate and Contribution of Abdominal Fat Distribution to Basal Metabolic Rate in Obese Japanese People
- Study Design and Organization of the JPHC Study
- Anthropometric and Clinical Findings in Obese Japanese: The Saku Control Obesity Program (SCOP)
- The Use of a Uniaxial Accelerometer to Assess Physical-activity-related Energy Expenditure in Obese Men and Women: Saku Control Obesity Program (SCOP)
- Dioxin exposure and type 2 diabetes mellitus: Case control study
- Congener-specific polychlorinated biphenyls and the prevalence of diabetes in the Saku Control Obesity Program (SCOP)
- Obese Japanese Adults with Type 2 Diabetes Have Higher Basal Metabolic Rates than Non-Diabetic Adults
- U-shaped relationship between body mass index and incidence of diabetes
- Pharmacokinetics of an Equol Supplement in Humans
- Validity of Diabetes Self-Reports in the Saku Diabetes Study
- Evaluation of effects of cassis (Ribes nigrum L.) juice on human vascular function and gene expression using a microarray system