Associations between Leukocyte Counts and Cardiovascular Disease Risk Factors in Apparently Healthy Japanese Men
スポンサーリンク
概要
- 論文の詳細を見る
Increased leukocyte counts, particularly white blood cell and neutrophil counts, are reportedly associated with increased incidence of cardiovascular diseases (CVD) and mortality in subjects with acute and moderate coronary diseases. However, few reports have determined the associations between leukocyte subset (i.e., white blood cells, neutrophils, monocytes, lymphocytes, basophils and eosinophils) counts and CVD risk factors. In this study, we examined the associations between leukocyte subset counts and CVD risk factors in apparently healthy Japanese men. We conducted a cross-sectional study of men who participated in health checkups, and selected those who were not being treated for metabolic diseases. We determined associations between leukocyte subset counts and CVD risk factors by multivariate linear regression (MLR) analysis and analysis of covariance (ANCOVA). Overall, 3,576 subjects aged 49.3±5.75 (range, 40-59) y were recruited. MLR and ANCOVA showed that white blood cell, neutrophil, monocyte counts are associated with decreased high-density lipoprotein cholesterol (HDL-C) and increased C-reactive protein levels, the lymphocyte count is positively associated with lipid abnormalities (i.e., decreased HDL-C, increased low-density lipoprotein cholesterol and increased triacylglycerol (TG)), and the basophil count is associated with increased TG and liver injury marker levels (i.e., alanine aminotransferase). Our results in this study demonstrated that leukocyte subset counts showed differential associations with CVD risk factors in apparently healthy Japanese men.
- 日本ビタミン学会、日本栄養・食糧学会の論文
著者
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Goda Toshinao
Laboratories Of Nutritional Physiology School Of Food And Nutritional Sciences The University Of Shi
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Mochizuki Kazuki
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And G
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Misaki Yasumi
Laboratory Of Nutritional Physiology And Global Coe Program University Of Shizuoka Graduate School O
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Miyauchi Rie
Laboratory Of Nutritional Physiology And Global Coe Program University Of Shizuoka Graduate School O
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KASEZAWA Nobuhiko
SBS Shizuoka Health Promotion Center
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TOHYAMA Kazushige
SBS Shizuoka Health Promotion Center
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Mochizuki Kazuki
Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences
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MISAKI Yasumi
Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences
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