Reduced Expression of β_2 Integrin Genes in Rat Peripheral Leukocytes by Inhibiting Postprandial Hyperglycemia
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概要
- 論文の詳細を見る
β2 integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions. The streptozotocin (STZ)-treated rats showed moderate postprandial hyperglycemia on days 1 and 4. The gene expression was higher for CD11a with fasting and 3-h postprandial on day 1, and with fasting on day 4, for CD11b with fasting on day 1 and 3-h postprandial on day 4, and for CD18 with fasting on days 1 and 4 in peripheral leukocytes from the STZ-treated rats than in peripheral leukocytes from the saline-treated rats. Miglitol reduced postprandial hyperglycemia and the gene expression of CD11a with fasting and of CD11b 3-h postprandial on day 4. These results indicate that inhibiting postprandial hyperglycemia reduced the mRNA expression of β2 integrins in peripheral leukocytes of moderately postprandial hyperglycemic rats.
- 社団法人 日本農芸化学会の論文
- 2010-12-23
著者
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Shimada Masaya
静岡県立大学 生活健康科学研究科栄養生理学研究室
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Goda Toshinao
Lab. Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And Global
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Goda Toshinao
Laboratories Of Nutritional Physiology School Of Food And Nutritional Sciences The University Of Shi
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Goda Toshinao
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And G
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Mochizuki Kazuki
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And G
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Mochizuki Kazuki
School Of Food And Nutritional Sciences The University Of Shizuoka
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SHIMADA Masaya
Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School
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Fukaya Nanae
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And T
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Tanaka Yutaro
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And T
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Shimada Masaya
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And T
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Shimada Masaya
Laboratory Of Nutritional Physiology And Global Coe Program University Of Shizuoka Graduate School O
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Mochizuki Kazuki
Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences
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