Variation in Gene Expression of Inflammatory Cytokines in Leukocyte-Derived Cells of High-Fat-Diet-Induced Insulin-Resistant Rats
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概要
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A high-fat diet is thought to enhance inflammation in various tissues by increasing insulin resistance. In this study, we determined the mRNA levels of inflammatory cytokines in leukocyte-derived cells in the blood of rats with high-fat-diet-induced insulin resistance. Feeding rats a high-fat diet for 77 d induced moderate insulin resistance, which was determined by increased plasma glucose and insulin concentrations, following an oral glucose tolerance test. The interleukin (IL)-1β mRNA level was higher in the insulin-resistant rats than in control rats at the fasting stage, whereas the tumor necrosis factor (TNF)-α mRNA level was greatly elevated at 180 min after glucose administration in the insulin-resistant rats. The results suggest that feeding rats a high-fat diet enhances the expression of fasting IL-1β and postprandial TNF-α genes in leukocyte-derived cells.
著者
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Goda Toshinao
Laboratories Of Nutritional Physiology School Of Food And Nutritional Sciences The University Of Shi
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Mochizuki Kazuki
Laboratory Of Nutritional Physiology Graduate School Of Nutritional And Environmental Sciences And G
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Mochizuki Kazuki
School Of Food And Nutritional Sciences The University Of Shizuoka
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SHIMADA Masaya
Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School
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FUJIMOTO Saki
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Glo
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MURAYAMA Yuki
Laboratory of Nutritional Physiology, Graduate School of Nutritional and Environmental Sciences, Glo
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