Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis
スポンサーリンク
概要
- 論文の詳細を見る
We performed proteomics analysis of the cerebrospinal fluid (CSF) of healthy dogs and dogs with meningoencephalitis of unknown etiology (MUE). By comparing two-dimensional electrophoreses (2DE), an upregulated spot was found in MUE dogs. This protein was identified as a neuron-specific enolase (NSE) by analysis with MALDI-TOF mass spectrometry. In comparing dot blots using an antibody against NSE, the NSE levels in the CSF of MUE dogs was significantly higher than that of the controls. NSE is a diagnostic marker of neuroendocrine tumors, brain injury and spinal cord trauma in humans. It seems that the NSE concentration in the CSF is increased by cellular destruction in canine encephalitis. Though elevation of NSE may not be specific in canine encephalitis because the NSE level was increased in other CNS diseases, further study including measurement with serum is necessary.
- 公益社団法人 日本獣医学会の論文
著者
-
Nomura Sachiko
Department Of Kinesiology Graduate School Of Science Tokyo Metropolitan University
-
Nakamura Kozo
Department Of Agricultural Chemistry The University Of Tokyo
-
Miyasho Taku
Department Of Veterinary Biochemistry School Of Veterinary Medicine Rakuno Gakuen University
-
Yokota Hiroshi
Department Of Applied Chemistry And Biotechnology Faculty Of Engineering Fukui University
-
NAKAMURA Kozo
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
-
YOKOTA Hiroshi
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
-
NAKADE Tetsuya
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
-
NAKADE Tetsuya
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
-
MIYASHO Taku
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
-
NOMURA Sachiko
Department of Veterinary Biochemistry, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan
関連論文
- Juxtacortical chondroma of the sacrum
- Diagnostic significance of gadolinium-enhanced MR imaging in the glomus tumour
- Identification of sequence polymorphisms in two sulfation-related genes, PAPSS2 and SLC26A2, and an association analysis with knee osteoarthritis
- Modified measurement of finger-floor distance : Self-assessment bending scale
- Nonself-centering Bateman bipolar endoprosthesis for nontraumatic osteonecrosis of the femoral head : a 12- to 18-year follow-up study
- Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee and hip joints
- Continuous Production of L-Alanine with NADH Regeneration by a Nanofiltration Membrane Reactor
- Separation of Caffeine from Supercritical Carbon Dioxide with a Zeolite Membrane
- Effect of Solute Adsorption Properties on Its Separation from Supercritical Carbon Dioxide with a Thin Porous Silica Membrane
- Disruption of Microbial Cells by the Flash Discharge of High-pressure Carbon Dioxide
- Prognostic Factors for Patients With Spinal Metastases From Lung Cancer
- Incidence and prognostic factors of Japanese breast cancer patients with bone metastasis
- Repeated postoperative laryngeal obstruction due to bilateral cricoarytenoid joint involvement in rheumatoid arthritis
- Signal transduction pathways regulating osteoclast differentiation and function
- The osteoclast: a potential therapeutic target of bone and joint destruction in rheumatoid arthritis
- Clinical use of a newly developed calcium phosphate cement (XSB-671D)
- Dielectric Relaxation of Aqueous Solution with Low-molecular-weight Nonelectrolytes and Its Relationship with Solution Structure
- Water Permeability of Plasma Membranes of Cultured Rice, Grape, and CH27 Cells Measured Dielectrically
- Freezing Injury of Cultured Rice Cells Analyzed by dielectric Measurement
- Activity and Activity Coefficient of Water in Aqueous Solutions and Their Relationships with Solution Structure Parameters
- Application of Shielded Hot-Wire Viscosity Sensor to Monitoring Cultivations of Xanthomonas campestris and Nicotiana tabacum BY-2
- Effects of Substrate Solubility in Interesterification with Triolein by Immobilized Lipase in Supercritical Carbon Dioxide
- Transesterification between Triolein and Ethylbehenate by Immobilized Lipase in Supercritical Carbon Dioxide
- Neurologic Level Diagnosis of Cervical Stenotic Myelopathy
- Spinal stenosis in grade I degenerative lumbar spondylolisthesis : a comparative study of outcomes following laminoplasty and laminectomy with instrumented spinal fusion
- Efficacy of tricyclic antidepressant for somatoform pain disorders with chronic lower back and leg pain
- High Mobility Group Box 1 (HMGB1) Protein Is Present in the Cerebrospinal Fluid of Dogs with Encephalitis
- Tumor necrosis factor-α inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways
- Instrumentation surgery for cervical instability in patients with athetoid cerebral palsy
- Age-related changes in histogram pattern of anterior horn cells in human cervical spinal cord
- Fusionless Surgery for Scoliosis : 2-17 Year Radiographic and Clinical Follow-Up
- Vertebral hemangioma compressing the thoracic spinal cord : application of computer-aided navigation and intraoperative spinal sonography for surgery through anterior and posterior approaches
- Revision cervical spine surgery using transarticular or pedicle screws under a computer-assisted image-guidance system
- Can Laminoplasty Maintain the Cervical Alignment Even When the C2 Lamina Is Contained?
- Postoperative Expansion of Intramedullary High-Intensity Areas on T2-Weighted Magnetic Resonance Imaging After Cervical Laminoplasty
- Retroodontoid pseudotumor resected by a high cervical lateral approach in a rheumatoid arthritis patient : a case report
- Cervical myelopathy in an adult due to atlantoaxial subluxation associated with Down syndrome : a case study
- Image-guided surgery for cervical disorders in rheumatoid arthritis
- Association of Bone Metabolism Regulatory Factor Gene Polymorphisms With Susceptibility to Ossification of the Posterior Longitudinal Ligament of the Spine and Its Severity
- Computer-assisted anterior spinal surgery for a case of recurrent giant cell tumor
- Long-Term Results of Operative Treatment for Cervical Spondylotic Myelopathy in Patients With Athetoid Cerebral Palsy : An Over 10-Year Follow-Up Study
- Long-Term Results of Double-Door Laminoplasty for Cervical Stenotic Myelopathy
- Diet and lifestyle associated with increased bone mineral density : cross-sectional study of Japanese elderly women at an osteoporosis outpatient clinic
- Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis
- Symptomatic cyclops lesion after rupture of the anteromedial bundle of the anterior cruciate ligament
- Factors associated with mortality following hip fracture in Japan
- Endoscopic anterior cruciate ligament reconstruction using a computer-assisted fluoroscopic navigation system
- Risk factors for knee osteoarthritis in Japanese men : a case-control study
- Tastes Produced by Peptides Containing Ionic Groups and by Related Compounds
- Analysis of Aggregate Structure in Food Protein Gels with the Concept of Fractal
- Fractal Analysis of Aggregates Formed by Heating Dilute BSA Solutions Using Light Scattering Methods
- Correction of tibial deformity in adults
- Further Studies on the Preparation of Low Sodium Chloride-containing Soy Sauce by Using Ornithyltaurine Hydrochloride and Its Related Compounds
- Preparation of Low Sodium Chloride Containing Soy Sauce Using Amino Acid Based Saltiness Enhancers
- Continuous Production of L-Carnitine with NADH Regeneration by a Nanofiltration Membrane Reactor with Coimmobilized L-Carnitine Dehydrogenase and Glucose Dehydrogenase
- Development of Taste Evaluation System of Monatin Related Compounds Using Computer Modeling Method
- Rate Analysis of the Freeze Drying of Liquid Foods by a Modified Uniformly Retreating Ice Front Model(Food & Nutrition)
- Rate Analysis of Freeze Drying of a Model System by a Uniformly Retreating Ice Front Model(Food & Nutrition)
- Development of a Model for Analyzing the Swelling Rate of Ionic Gels on the Basis of the Diffusion of Mobile Ions: Application to the pH-Sensitive Swelling of a Polyelectrolyte Complex Gel Prepared from Xanthan and Chitosan
- Analysis of the pH-Sensitive Swelling Rate of a Polyelectrolyte Complex Gel Prepared from Xanthan and Chitosan by the Collective Diffusion Model
- Method for Analyzing pH-Sensitive Swelling of Amphoteric Hydrogels : Application to a Polyelectrolyte Complex Gel Prepared from Xanthan and Chitosan
- Effects of Antithrombin III on Spinal Cord-Evoked Potentials and Functional Recovery After Spinal Cord Injury in Rats
- Impact of biologics on the prevalence of orthopedic surgery in the National Database of Rheumatic Diseases in Japan
- Prediction of Vertebral Strength Under Loading Conditions Occurring in Activities of Daily Living Using a Computed Tomography-Based Nonlinear Finite Element Method
- Nonlinear Finite Element Model Predicts Vertebral Bone Strength and Fracture Site
- The Efficacy of Prostaglandin E1 Derivative in Patients With Lumbar Spinal Stenosis
- Comparison of pH and Ionic Strength Dependence of Interactions between Monoclonal Antibodies and Bovineβ-Lactoglobulin
- A Unique Mechanism of Giving Way of the Knee After Tibial Plateau Fracture
- Mutation in Aging Suppressor Gene, Klotho, Causes Decreases in Bone Formation and Resorption in Mice(Advances in Connective Tissue Research in Bone and Joint)
- A novel therapeutic vaccine approach, targeting RANKL, prevents bone destruction in bone-related disorders
- Spindle cell lipoma of the knee : a case report
- Possible Role of Nitric Oxide on Adipocyte Lipolysis in Exercise-Trained Rats
- Juxtacortical osteoma of the ulna
- Statistics for orthopedic surgery 2006-2007 : data from the Japanese Diagnosis Procedure Combination database
- Enzymatic Interesterification in Supercritical Carbon Dioxide(Food & Nutrition)
- Usefulness of absorbable screws in the Sauve-Kapandji procedure for rheumatoid wrist reconstruction
- Involuted intraosseous lipoma of the sacrum showing high signal intensity on T1-weighted magnetic resonance imaging (MRI)
- A polymorphic variant at the Werner helicase(WRN)gene is associated with bone density, but not spondylosis, in postmenopausal women
- Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women : the research on osteoarthritis/osteoporosis against disability study
- Satisfaction and the Correlative Outcomes in Cervical Laminoplasty
- Association of low dietary vitamin K intake with radiographic knee osteoarthritis in the Japanese elderly population : dietary survey in a population-based cohort of the ROAD study
- The Effect of Endurance Training on Secreting Adipocyokine
- The Effect of Endurance Training on A-kinase Subtypes in Adipocyte
- Intraoperative Ultrasonographic Evaluation of Posterior Decompression by Laminoplasty in Patients with Cervical Ossification of the Posterior Longitudinal Ligament : Correlation with Two-year Follow-up Results
- Diameter, Length, and Direction of Pedicle Screws for Scoliotic Spine : Analysis by Multiplanar Reconstruction of Computed Tomography
- Impact of knee and low back pain on health-related quality of life in Japanese women : the Research on Osteoarthritis Against Disability (ROAD)
- Inactivation of Food Microorganisms by High-pressure Carbon Dioxide Treatment with or without Explosive Decompression
- Lethal Effect of High-Pressure Carbon Dioxide on a Bacterial Spore
- Rheumatoid arthritis associated with osteopetrosis
- 症例報告 L2/3 disc herniation caused weakness of the contralateral gastrocnemius and soleus muscles: a case report (日本腰痛学会特集号)
- Spatial Relations Between the Vertebral Body and the Thoracic Aorta in Adolescent Idiopathic Scoliosis
- Bipolar revision arthroplasty for failed threaded acetabular components : radiographic evaluation of cup migration
- Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system
- Normal and threshold values of radiographic parameters for knee osteoarthritis using a computer-assisted measuring system (KOACAD) : the ROAD study
- ELECTRO-ULTRAFILTRATION OF REVERSE MICELLES CONTAINING ENZYME
- Relation between Fat Distributions and Several Plasma Adipocytokines after Exercise Training in Premenopausal and Postmenopausal Women
- The relationships between fat distribution and plasma adipocytokines(Leptin, PAI-1) : the effects of exercise training
- Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity
- Proteome Analysis of Cerebrospinal Fluid in Healthy Beagles and Canine Encephalitis
- Recent advances in the adaptations of adipose tissue to physical activity : Morphology and adipose tissue cellularity