Efficacy of Contrast-Enhanced Ultrasonography in Radiofrequency Ablation for Hepatocellular Carcinoma

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概要

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• Objective Local recurrence after radiofrequency ablation (RFA) is a major problem that needs to resolved to increase the survival rate of hepatocellular carcinoma (HCC). CE-US with Sonazoid®, the second-generation contrast media, can detect smaller HCC lesions and the detection rate of ultrasonically unrecognized hypervascular HCC was improved by CE-US. The aim of the present study was to evaluate the role of CE-US with Sonazoid® in improving radicality and reducing local recurrence after RFA for HCC. Patients and Methods A total of 102 nodules treated by RFA at our hospital from January 2006 to October 2009 were enrolled: 31 nodules were treated without CE-US, since CE-US was not yet available (Group A), and 71 nodules were treated with a combination of RFA and CE-US with Sonazoid® (Group B). Results The clinical characteristics (sex, virus marker, Child-Pugh grade, with or without transcatheter arterial infusion chemotherapy with lipiodol, and T factor) did not differ significantly between group A and group B. Mean age was significantly older and tumor size was significantly larger in group B. Group B had significantly better radicality compared with group A. The non-local recurrence rate was significantly higher in group B as compared with group A. Conclusion CE-US with Sonazoid® greatly helps to improve RFA efficacy in HCC treatment. We suggest that the ability of CE-US with Sonazoid® to detect an accurate area of HCC before RFA and to immediately detect a residual tumor during RFA might contribute to an increase of the radicality and reduction of local recurrence after RFA.

著者

• Kataoka Ei

  Department Of Gastroenterology Akita University School Of Medicine

• Ishii Hajime

  Department Of Gastroenterology Akita University School Of Medicine

• Anezaki Yumiko

  Department Of Gastroenterology Akita University School Of Medicine

• Shibuya Tomomi

  Department Of Gastroenterology Akita University School Of Medicine

• Dohmen Takahiro

  Department Of Gastroenterology Akita University School Of Medicine

• Ohshima Shigetoshi

  Department Of Electrical And Information Engineering Faculty Of Engineering Yamagata University

• Miura Kouichi

  Department Of Applied Chemistry Kanagawa Institute Of Technology

• Segawa Daisuke

  Department Of Fermentation Technology Faculty Of Engineering Hiroshima University

• Ohnishi Hirohide

  Department Of Gastroenterology Akita University Graduate School Of Medicine /department Of Gastroent

• Sato Wataru

  Department Of Environmental And Health Science Tohoku Pharmaceutical University

• Yamada Ikuhiro

  Departments of Gastroenterology Akita University Graduate School of Medicine

• Kamada Kentaro

  Department of Gastroenterology, Akita University Graduate School of Medicine

• Goto Takashi

  Department of Applied Chemistry, Faculty of Engineering

• Ohnishi Hirohide

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Shibuya Tomomi

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Kamada Kentaro

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Anezaki Yumiko

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Ishii Hajime

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Dohmen Takahiro

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Miura Kouichi

  Department of Gastroenterology, Akita University Graduate School of Medicine, Japan

• Ishii Hajime

  Department of Chemistry, Faculty of Science, Kyushu University

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