Acute Combined Central and Peripheral Demyelination Showing Anti-Aquaporin 4 Antibody Positivity
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概要
- 論文の詳細を見る
Neuromyelitis optica spectrum disorder (NMOSD) is characterized by optic neuritis or transverse myelitis with anti-aquaporin 4 (AQP4) antibodies (1). We herein present the case of a patient with NMOSD who also was affected with peripheral neuropathy. A 58-year-old woman developed gait disturbance and sensory impairment in the lower limbs. She exhibited longitudinally extensive transverse myelitis with anti-AQP4 antibodies. Nerve conduction studies showed demyelinating changes. Laboratory findings showed hepatitis-C virus (HCV) infection. Her peripheral neuropathy improved after immunotherapy. There have been no previous reports of NMO or NMOSD associated with neuropathy. The HCV infection or undetermined humoral factors other than the anti-AQP4 antibodies may have caused her peripheral neuropathy.
著者
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Kusunoki Susumu
Department Of Neurology Graduate School Of Medicine University Of Tokyo
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Mitsui Yoshiyuki
Department Of Neurology Kinki University School Of Medicine
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Suzuki Hidekazu
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Miyamoto Katsuichi
Department Of Immunology National Institute Of Neuroscience National Center Of Neurology And Psychia
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Takahashi Toshiyuki
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
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FUJIHARA Kazuo
Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine
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Kitada Mari
Department of Neurology, Kinki University School of Medicine, Japan
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Ichihashi Juri
Department of Neurology, Kinki University School of Medicine, Japan
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Inada Rino
Department of Neurology, Kinki University School of Medicine, Japan
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Miyamoto Katsuichi
Department of Neurology, Kinki University School of Medicine, Japan
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