Prognostic Factors in Malignant Pleural Mesothelioma: A Retrospective Study
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概要
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Objective The incidence of malignant pleural mesothelioma (MPM) in Japan is predicted to increase over the next few decades. Prognostic factors remain unclear although several studies have reported this disease. In this study, we examined the prognostic factors of MPM from single institution practice data and tested the scoring systems of past reports. Methods We retrospectively obtained clinical data from the medical records of patients who were diagnosed with MPM from 1991 to 2010. The European Organization for Research and Treatment of Cancer prognostic score (EPS) was calculated. Results We surveyed the records of 68 patients. Univariate analysis showed that significant prognostic factors were histological type, stage, performance status (PS), chemotherapy, and lactate dehydrogenase (LD). Multivariate analysis identified stage, PS and LD as independent prognostic factors. Low-risk group (EPS ≤1.27) survival was significantly better than that of the high-risk group (EPS >1.27) (17.0 months vs. 8.0 months; p=0.002). Conclusion Stage, PS and LD were demonstrated to be independent prognostic factors. An EPS >1.27 was still considered a poor prognosis indicator in the practice data of MPM.
著者
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Okamoto Norio
Department Of Ophthalmology Ntt West Osaka Hospital
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HIRASHIMA Tomonori
Department of Internal Medicine, Osaka Prefectural Habikino Hospita
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Kawase Ichiro
Department Of Hematology And Rheumatology Tohoku University Graduate School Of Medicine
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Suzuki Hidekazu
Department Of Cellular Biology Research Institute For Radiation Biology And Medicine Hiroshima Unive
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Kobayashi Masashi
Department Of Clinical Pharmacology Toyama Medical & Pharmaceutical University
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MORITA Satomu
Department of Internal Medicine, Toyonaka Municipa Hospital
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Hirashima Tomonori
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Tamiya Motohiro
Department of Thoracic Malignancy, Osaka Prefectural Hospital Organization Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Morishita Naoko
Department of Thoracic Malignancy, Osaka Prefectural Hospital Organization Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Tamiya Motohiro
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Kawase Ichiro
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Matsuura Yuka
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Morimura Osamu
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Okafuji Kohei
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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Shiroyama Takayuki
Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan
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