Effect of nicorandil on cerebral vasospasm.

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N-(2-hydroxyethyl) nicotinamide nitrate (nicorandil), a newly developed anti-anginal drug, is a coronary vasodilator whose action is comparable to papaverine. We examined this drug to determine whether it could be useful in relieving cerebral vasospasm using helical cut dog basilar artery (in vitro) and vasospasm model dog (in vivo). In each vessel stimulated to contract by PGF2α, U-46619 or K+, the addition of nicorandil (10-9-10-4M) caused dose-dependent and persistent relaxation. In the basilar arteries, con tractions induced by PGF2α and U-46619 were attenuated by prior treatment with nicorandil, but contractions induced by K+ were not. Twice-a-day intravenous injection of nicorandil could not prevent vasospasm in the model dogs. But, intrathecal injection of nicorandil caused marked dilatation of the spastic basilar artery of model dogs. In in vitro experiments, nicorandil dilated a basilar artery which was constricted by various spasmogenic substances and the prior treatment with nicorandil had attenuated the contractile responses to endogenous prostaglandins, which are known to play an important role in cerebral vasospasm. In in vivo experiments, owing to the short half-life of nicorandil, intravenous injection could not prevent cerebral vasospasm: however, intrathecal injection showed a marked effectiveness. In conclusion, we think nicorandil may be useful for the treatment and prophylaxis of cerebral vasospasm with an adequate usage.
一般社団法人日本臨床薬理学会の論文

Effect of nicorandil on cerebral vasospasm.

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