Crystal and molecular structure of mitomycin C, an anticancer antibiotic.

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概要

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• The crystal structure of mitomycin C was determined by means of X-ray diffraction. Mitomycin C was crystallized in the orthorhombic space group P2<SUB>1</SUB>2<SUB>1</SUB>2<SUB>1</SUB>, with <I>a</I>=12.887, <I>b</I>=13.851, <I>c</I>=9.718 Å, and <I>Z</I>=4, and its structure solved by the trial and error method using the rigid-body approximation. The absolute configuration was determined by referring to that of <I>N</I>-(<I>p</I>-bromobenzoyl) mitomycin C. The carbamoyloxymethyl side chain participates in hydrogen bonds as in the case of other mitomycins in the crystalline state.

• 公益社団法人 日本化学会の論文

著者

• NOMURA Akiko

  Faculty of Engineering, Kanagawa University

• Fujiwara Takaji

  Faculty Of Pharmaceutical Sciences Of Osaka University

• TOMITA Ken-ichi

  Faculty of Pharmaceutical Sciences of Osaka University

• Ogawa Keizo

  Faculty of Pharmaceutical Sciences, Osaka University

• Fujiwara Takaji

  Faculty of Pharmaceutical Sciences, Osaka University

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