Structural Studies of Tryptophan Metabolites by X-ray Diffraction Method. II. The Crystal and Molecular Structure of Tryptamine Hydrochloride

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概要

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• The crystal structure of tryptamine hydrochloride has been solved by the application of the symbolic addition method, and refined by successive Fourier syntheses and least-squares procedures. The crystals are orthorhombic, space group Pbca, with lattice parameters <I>a</I>=8.545, <I>b</I>=10.025 and <I>c</I>=24.252 Å. All the positions of hydrogen atoms were found in the difference Fourier map and included in the refinement. The ethylamine side chain bound to the indole ring is in a folded configuration as found in the crystal structure of serotonin picrate monohydrate. A weakly basic nitrogen atom of the indole ring takes part in the hydrogen bonding with the adjacent ion. Every chloride ion behaves as an acceptor for four hydrogen bonds. This is in line with the absence of any marked cleavage where indole rings are packed together to form a pleated sheet and a three-dimensional network structure is essentially stabilized by the hydrogen bond formation.

• 公益社団法人 日本化学会の論文

著者

• Fujiwara Takaji

  Faculty Of Pharmaceutical Sciences Of Osaka University

• TOMITA Ken-ichi

  Faculty of Pharmaceutical Sciences of Osaka University

• Wakahara Akio

  Faculty of Pharmaceutical Sciences, Osaka University

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