The interaction between .ALPHA.-helical poly-L-lysine and thyroxine as measured by circular dichroism.

スポンサーリンク

概要

• 論文の詳細を見る

• The interaction between α-helical poly-L-lysine (poly(L-Lys)) and the thyroid hormone, L-thyroxine (L-T<SUB>4</SUB>), was investigated at pH 11 by means of circular dichroism (CD) measurements in the wavelength region of 200–380 nm. At least four CD bands were induced near 235, 250, 290, and 343 nm. This indicates that these induced Cotton effects occurred as the result of the binding of L-T<SUB>4</SUB> to poly(L-Lys), probably due to the electrostatic interaction. The wavelengths of the induced GD bands corresponded to those of the UV absorption bands of L-T<SUB>4</SUB> in the poly(L-Lys) : L-T<SUB>4</SUB> mixture, although small red-shifts of the CD bands were observed at the shortest and the longest wavelengths (235 nm and 343 nm). These CD bands might be interpreted by the fixed intramolecular orientation around an asymmetric α-carbon atom of the bound L-T<SUB>4</SUB> or by the intermolecular interaction between the peptide backbone of poly(L-Lys) and the bound L-T<SUB>4</SUB>.

• 公益社団法人 日本化学会の論文

著者

• Okabe Nobuo

  Faculty Of Pharmaceutical Sciences Kinki University

• TOMITA Ken-ichi

  Faculty of Pharmaceutical Sciences of Osaka University

• Okamura Mariko

  Faculty of Pharmaceutical Sciences, Osaka University

• Tokuoka Ryoji

  Faculty of Pharmaceutical Sciences, Osaka University

• Okabe Nobuo

  Faculty of Pharmaceutical Sciences, Osaka University

関連論文

• Crystal Structures of Palladium(II) Ternary Complexes of 5-X-2-Aminobenzoic Acid with 1,10-Phenanthroline and Their Interaction with Calf Thymus DNA (Where X=Cl, Br and I)
• X-Ray Diffraction Studies of Polyhedral Inclusion Bodies of Nuclear and Cyto-Plasmic Polyhedrosis Viruses
• X-Ray Structure Characterization of Palladium (II) Ternary Complexes of Pyridinedicarboxylic and Phthalic Acid with Phenanthroline and Bipyridine
• Crystal Structures and Spectroscopic Properties of Zinc(II) Ternary Complexes of Vitamin L, H′ and Their Isomer m-Aminobenzoic Acid with Bipyridine
• Structures and DNA-Binding and Cleavage Properties of Ternary Copper(II) Complexes of Glycine with Phenanthroline, Bipyridine, and Bipyridylamine
• Structures and Interaction with DNA of Ternary Palladium(II) Complexes : [Pd(Gly)(X)] (Gly=Glycine; X=2,2'-Bipyridine, 1,10-Phenanthroline and 2,2'-Bi-pyridylamine)
• Structural studies of the interaction between indole derivatives and biologically important aromatic compounds. IV. The crystal and molecular structure of tryptamine:adenin-9-ylacetic acid(1:1)hemihydrate complex.
• The crystal and molecular structure of N-(thioacetyl)tryptamine. A radioprotective indole compound.
• Crystal and Molecular Structure of ω-Amino Acids, ω-Amino Sulfonic Acids and Their Derivatives. II. The Crystal and Molecular Structure of α-Form of 3-Aminopropane Sulfonic Acid, Homotaurine
• Structure of a potent antithyroid drug, 6-propyl-2-thiouracil.
• The interaction between .ALPHA.-helical poly-L-lysine and thyroxine as measured by circular dichroism.
• Crystal and Molecular Structure of ω-Amino Acids, ω-Aminosulfonic Acids and Their Derivatives. V. Crystal and Molecular Structure of γ-Guanidino Propane Sulfonic Acid
• Crystal and molecular structure of mitomycin C, an anticancer antibiotic.
• The crystal and molecular structure of zinc complex of 2-chlorobenzoic acid. I. The crystal and molecular structure of bis(2-chlorobenzoato)zinc(II).
• Crystal and Molecular Structure of ω-Amino Acids, ω-Amino-Sulfonic Acids and Their Derivatives. VII. The Crystal and Molecular Structure of DL-Carnitine Hydrochloride
• Crystal and Molecular Structure of ω-Amino Acids, ω-Aminosulfonic Acids and Their Derivatives. VI. The Crystal and Molecular Structure of DL-γ-Amino-β-hydroxybiityric Acid (GABOB), A Nervous Inhibitory Chemical Transmitter
• The crystal and molecular structure of zinc complex of 2-chlorobenzoic acid. II. The crystal and molecular structure of .MU.3-hydroxo-tri-.MU.-(2-chlorobenzoato)dizinc(II) dihydrate.
• Structural Studies of Tryptophan Metabolites by X-ray Diffraction Method. I. The Crystal and Molecular Structure of 5-Hydroxy-DL-Tryptophan
• Crystal and Molecular Structure of ω-Amino Acids, ω-Aminosulfonic Acids and Their Derivatives. I. The Crystal and Molecular Structure of γ-Guanidinobutyric Acid Hydrochloride and Hydrobromide
• Crystal and Molecular Structure of ω-Amino Acids, ω-Amino Sulfonic Acids and Their Derivatives. IV. The Crystal and Molecular Structure of γ-Aminobutyric Acid (GABA), a Nervous Inhibitory Transmitter
• The Crystal and Molecular Structure of Tyramine Hydrochloride
• Structural Studies of Tryptophan Metabolites by X-ray Diffraction Method. II. The Crystal and Molecular Structure of Tryptamine Hydrochloride
• Structural studies of the interaction between indole derivatives and biologically important aromatic compounds. II. The crystal and molecular structure of the tryptamine-phenylacetic acid (1:1) complex.
• Molecular conformations of .GAMMA.-aminobutyric acid and .GAMMA.-amino-.BETA.-hydroxybutyric acid in aqueous solution.
• Structural Studies of Tryptophan Metabolites by X-ray Diffraction Method. III. The Crystal and Molecular Structure of 5-Methoxyindole-3-acetic Acid
• Structural studies of the interaction between indole derivatives and biologically important aromatic compounds. I. The crystal and molecular structure of the indole-3-acetic acid-nicotinamide (1:1) complex.
• Crystal and molecular structure of .OMEGA.-amino acids, .OMEGA.-aminosulfonic acids and their derivatives. IX. Crystal and molecular structure of 3-amino-2-hydroxy-1-propanesulfonic acid.
• Crystal and Molecular Structure of ω-Amino Acids, ω-Aminosulfonic Acids and Their Derivatives. III. The Crystal and Molecular Structure of γ-Guanidino-β-hydroxypropane Sulfonic Acid
• The Crystal Structure of 1-Ethyl-5-bromouracil. I. The Crystal Structure of the Form I Crystal of 1-Ethyl-5-bromouracil

もっと見る 閉じる

スポンサーリンク