Structural studies of the interaction between indole derivatives and biologically important aromatic compounds. II. The crystal and molecular structure of the tryptamine-phenylacetic acid (1:1) complex.

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概要

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• The title complex crystallizes in the monoclinic space group of P2<SUB>1</SUB>/c. The unit-cell dimensions are <I>a</I>=6.673(4), <I>b</I>=19.017(8), <I>c</I>=13.394(7) Å, and β=110.54(2)°. The crystal structure was solved by a direct method. By block-diagonal least-squares refinements, the <I>R</I>-value converged to 0.062. In this complex, a salt bridge is found between the anionic carboxyl group of phenylacetic acid (PAA) and the cationic amino group of tryptamine (TPA). All the hydrogen atoms attached to the nitrogen atoms participate in the hydrogen bonding. The two complex molecules are hydrogen-bonded around a center of symmetry to form one unit, which is held together by van der Waals contacts in the b- and c-directions. Each unit is also stabilized by forming a hydrogen bond with the unit of the neighboring cell translated in the a-direction.

• 公益社団法人 日本化学会の論文

著者

• INOUE Masatoshi

  Osaka Gastric Cancer Chemotherapy Group, Second Department of Surgery, Osaka University Medical Scho

• Fujiwara Takaji

  Faculty Of Pharmaceutical Sciences Of Osaka University

• TOMITA Ken-ichi

  Faculty of Pharmaceutical Sciences of Osaka University

• Sakaki Toshimasa

  Osaka College of Pharmacy

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