Effects of bivalent metal cations on the conformation and aggregation of poly(L-glutamic acid).
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概要
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In the solution of fully neutralized poly(L-glutamic acid) in the absence of supporting electrolytes, the α-helix was induced by the addition of five transition metal chlorides in the following order: CuCl<SUB>2</SUB>\gtrsimCdCl<SUB>2</SUB>>ZnCl<SUB>2</SUB>>NiCl<SUB>2</SUB>>CoCl<SUB>2</SUB>. The induction did not occur by the addition of BaCl<SUB>2</SUB>, CaCl<SUB>2</SUB>, or MgCl<SUB>2</SUB>. The induction by transition metal cations was inhibited in the presence of a supporting electrolyte (NaCl). Distortion of circular dichroism (CD) spectra occurred as the induction of the α-helix proceeded, which was shown to be recognizable when apparent aggregation number <I>m</I> exceeded about 100. Conformation of the polypeptide in these aggregates was expected to be the α-helix based on the conformation in the precipitates obtained at these mixing ratios which gave distorted CD spectra, which was determined by infrared absorption spectra.
- 公益社団法人 日本化学会の論文
著者
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Maeda Hiroshi
Department Of Advanced Materials Science And Engineering Graduate School Of Engineering Yamaguchi Un
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Ikeda Shoichi
Department of Biology, Osaka University
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Hiramatsu Tsuyoshi
Department of Chemistry, Faculty of Science, Nagoya University
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