乳癌患者におけるTRH試験による血清TSH, T4およびT3の変化

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Twenty-six patients with breast cancer were intravenously injected with 500 μg of synthetic TRH. With one exception, none had received any treatment for breast canser. Blood samples were taken at intervals of 10, 20, 30, 40, 60, 90 and 120 min after the TRH-injection. Basal serum TSH values of those patients were significantly higher than those of normal subjects. Their serum TSH responses to TRH-injection were moderately delayed and higher when compared to those of normal subjects. Serum T4 values of the patients with breast cancer determined 120 min after the TRH-injection were significantly lower than those of normal subjects. However, serum T3 values of the same patients obtained 60min after the TRH-injection were signicantly higher than those of normal subjects. Serum T4/T3 ratios of breast cancer measured 60 min after the TRH-injection were significantly lower than those of normal subjects. These data suggest that thyroid function in patients with breast cancer may be suppressed. One patient with breast cancer also had adenomatous goiter. Two other patients with breast cancer were hypothyroid. One patient with breast cancer who received chemotherapy for 4 days before the TRH-injection showed a high basal serum TSH value, delayed and high TSH-response and lack of serum T4 response to the TRH-injection. Tests for anti-TG and anti-MC antibodies were positive in one patient with breast cancer, for anti-TG antibody in two patients and for anti-MC antibody in two other patients.
日本内分泌学会の論文

乳癌患者におけるTRH試験による血清TSH, T<SUB>4</SUB>およびT<SUB>3</SUB>の変化

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