甲状腺機能充進症におけるthyroxine binding globulinのthyroxineに対するaffinityの検討

概要

論文の詳細を見る
The meaning or elevated serum percent free thyroxine (% FT4) in patients with hyperthyroidism was investigated by the dialysis method. The mean % FT4 was 0.0340% in patients with hyperthyroidism, and the value was significantly higher than that (0.0178%) in euthyroid controls. The enriching normal sera with cold T4 to give the same concentration of T4 as the one in patients with hyperthyroidism resulted in no significant increase of % FT4 in a phosphate buffer. % FT4 increased significantly in a barbital buffer not only in normal sera enriched with T4 but also in hyperthyroid sera. Moreover, % FT4 in thyroid hormone free sera of hyperthyroid patients prepared by charcoal was 0.0209%, significantly lower than the value in the original one. Serum TBG concentration in patients with hyperthyroidism was 18.4μg/ml, which was not different from that in the euthyroid control, but it increased significantly after treatment with antithyroid drugs. In patients with hyper-thyroidism, the association constant of TBG for T4 measured by equilibrium dialysis was 3.15 X 109M-1, and the value was significantly lower than that (7.55 × 109M-1) in the euthyroid control. The association constant increased significantly after treatment with antithyroid drugs for hyperthyroidism. From these results it is likely that the elevated % FT4 in sera of patients with hyperthyroidism is ascribed to their decreased association constant of TBG for T4 as well as to both their diminished TBG concentration and the increased total T4 concentration.
日本内分泌学会の論文

甲状腺機能充進症におけるthyroxine binding globulinのthyroxineに対するaffinityの検討

スポンサーリンク

概要

著者

関連論文

スポンサーリンク