小児鼻アレルギー患者のダニ抗原に対する末梢血単核細胞応答

概要

論文の詳細を見る
In the present study, we investigated the cellular response of lymphocytes to house dust mite <I>(Dermatophagoides pteronyssinus)</I> and its fractionated antigens in pediatric nasal allergy. In response to crude antigen, lymphocytes derived from patients showed elevated proliferation and cytokine production in comparison with healthy subjects (p <0.01). Moreover, pediatric patients exhibited a more potent reaction than adult patients. By stimulation with fractions, patients showed a significant response at 95 and 15 KD (p<0.01). Futher, the group of pediatric patients had a tendency to react with fractions from 20 to 30 KD compared with the group of adult patients. These results may reflect the active immunological state in the pediatric atopic period.
Japan Society for Pediatric Otorhinolaryngologyの論文