Long-acting Phenphormin (DBI-Timed-Disintegration-Capsule) による糖尿病の治療経験

概要

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Long acting phenphormin in 50mg or 100mg timed-disintegration capsules (DBI-TD-Capsule) were used to treat 22 diabetics previously managed with diet alone, sulfonylureas or insulin. DBI-TD-Capsule was considered effective if there was more reduction than 10 Units/day in the previously required dose of insulin, or if the fasting blood sugar levels reduced below 140mg/d1. and daily urinary sugar reduced below 10g/day. By these criteria an effective response occured in 91 per cent of the patients. DBI-TD-Capsule was effective to all types of diabetics, especially the combined use with insulin was more effective than any other oral hypoglycaemic agents. DBI-TD 50mg capsules of twice daily administration were sufficient to secure the desired blood sugar level of control. Seven patients complained of gastro-intestinal symptoms, but these were soon relieved when the gastro-intestinal medicines were given. Except of these symptoms, there was no significant side effect. So it must be noted that it was never necessary to discontinue the administration of DBI-TD-Capsule in anyone.
日本内分泌学会の論文