Clinical Effect of Furosemide-Retard (Hoe 058 R) in Essential Hypertension:A Double Blind Controlled Study with Furosemide Tablets

概要

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The objective of this study was to compare the antihypertensive effect, usefulness and side effects (especially pollakiuria and polyuria) of two dosage forms of furosemide by the cross-over method. 1. Antihypertensive effect Blood-pressure was significantly lowered by both dosage forms compared with pre-treatment values. There was no significant difference between the antihypertensive effect of the two preparations. 2. Side effects The incidence of pollakiuria and polyuria in the Hoe 058R group was signi- ficantly less than that in the furosemide-tablet group. 3. Usefulness 1) Investigator's evaluation There was no significant difference between the two forms of furosemide. 2) Central Committee's evaluation Hoe 058 R was significantly superior to furosemide tablets when admini-stered initially prior to cross-over.
一般社団法人日本臨床薬理学会の論文