Pyridoxal-DL-dihydro-α-lipoic acid mercaptalおよびPyridoxalphosphate-DL-dihydro-α-lipoic acid mercaptalの研究

概要

論文の詳細を見る
It is well known that some of the vitamin B_6 enzymes need metal ions and thiol group with pyridoxal phosphate. Taking this in mind, the authors synthesized pyridoxal-DL-dihydro-α-lipoic acid mercaptal hydrochloride and pyridoxal phosphate-DL-dihydro-α-lipoic acid mercaptal from pyridoxal or pyridoxal phosphate and lipoic acid and investigated the physiological activity of them. They had both the vitamin B_6 and lipoic activities which were increased by the acid hydrolysis. The amount of vitamin B_6 and pyridoxal phosphate in the liver increased by an subcutaneous injection on vitamin B_6 deficient rats. These compounds showed some preventing effect on histological changes of liver cells due to CCL_4.
日本ビタミン学会の論文
1961-06-25