Overexpression of Interleukin 2 Receptor, Thymidine Kinase and Immunoglobulin-Associated Alpha-1 Messenger RNA in a Clinical Case of Enzootic Bovine Leukosis

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概要

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• A 49-month-old Holstein cow with anorexia, tachypnea, enlarged peripheral lymph nodes, and difficulty standing up was suspected of bovine leukosis. Hematological examination revealed lymphocytosis with the presence of neoplastic cells. Increased total lactate dehydrogenase (LDH) activity, isozymes of LDH-2 and LDH-3 activities and thymidine kinase activity were observed. Cytological findings of fine needle aspiration of subiliac lymph nodes indicated lymphosarcoma. Histopathology and antibody analysis confirmed the diagnosis of enzootic bovine leukosis, a B-cell bovine lymphoma caused by bovine leukemia virus. Gene expressions known as biomarkers of hematopoietic neoplasia in human were also examined in the present case. Increased messenger RNA expression of interleukin 2 receptor, thymidine kinase, and immunoglobulin-associated alpha-1 was observed in the case animal.

著者

• Kobayashi Yoshiyasu

  Department Of Pathology Hokkaido University School Of Medicine

• Sugimoto Kazuya

  Department Of Orthopaedic Surgery Saiseikai Nara Hospital

• TAGAWA Michihito

  Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine

• Inokuma Hisashi

  Department Of Applied Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine

• ITOH Yuuki

  Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

• TAWFEEQ Mohammad

  Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

• KOBAYASHI Yoshiyasu

  Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

• TAGAWA Michihito

  Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

• SUGIMOTO Kazuya

  Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine

• TAGAWA Michihito

  Department of Clinical Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080–8555, Japan

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