The Prokinetic Effect of Mosapride Citrate on Horse Gastric Emptying Rates
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概要
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The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was orally administerd at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Δ13CO2), an indirect indicator for the rate of gastric empting, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride may facilitate the gastric emptying in horses.
著者
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Sasaki Naoki
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
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Yamada Haruo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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OKAMURA Koichi
The United Graduate School of Veterinary Sciences, Gifu University
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FUKUNAKA Morito
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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Inokuma Hisashi
Department Of Applied Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine
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