Use of 13C-Acetate Breath Test for Assessment of Gastric Emptying in Horses
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概要
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This study aimed to establish and standardize a breath test that uses <sup>13</sup>C-acetate in a liquid diet for evaluation of gastric emptying in horses. Seven adult healthy thoroughbreds were used in this study. They were given <sup>13</sup>C-acetate (125 mg, 250 mg, or 500 mg) in a test meal (2000 m<i>l</i> liquid diet) via an intranasal catheter. <sup>13</sup>C concentrations in the exhaled CO<sub>2</sub> were measured in samples taken before and after test meal administration using an infrared absorption spectroscope. In the 500 mg <sup>13</sup>C-acetate group, Δ<sup>13</sup>CO<sub>2</sub> showed a steep gradient immediately after meal administration compared to the 125 mg and 250 mg groups. Therefore, t<sub>max</sub> in the 500 mg group was easier to determine than in the 125 mg and 250 mg groups. In the 500 mg group, GEC, half-empty time (t1/2), calculated t<sub>max</sub> (t<sub>lag</sub>), and t<sub>max</sub> were 1.95 ± 0.28 (mean ± SD), 229.2 ± 57.0 (min), 139.2 ± 22.2 (min), and 124.0 ± 28.4, respectively. Differences in CV observed in the 500 mg group were lower than those in the 125 mg and 250 mg groups. This study demonstrates that the <sup>13</sup>C-acetate breath test is useful for evaluating gastric emptying in horses since it is non-invasive and does not require set up of special facilities or equipment. Optimum evaluation of gastric emptying in horses can be achieved with 500 mg of <sup>13</sup>C-acetate given in a liquid diet.<br>
著者
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Sasaki Naoki
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
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Yamada Haruo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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SASAKI Naoki
Department of Veterinary Surgery, Obihiro University of Agriculture and Veterinary Medicine
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AIUCHI Hanako
Department of Veterinary Surgery, Obihiro University of Agriculture and Veterinary Medicine
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