Pharmacokinetics of the Gastroprokinetic Agent Mosapride Citrate after Single Oral Administration in Horses
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概要
- 論文の詳細を見る
The purpose of this study was to determine the pharmacokinetics and dose proportionality of mosapride citrate, a selective 5-HT4 agonist, after oral administration in horses. Seven healthy Thoroughbreds were dosed with distilled water and 0.5, 1.0, or 1.5 mg/kg mosapride citrate through a nasogastric tube. Serum mosapride concentrations were measured by a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method. Mosapride showed the Cmaxs of 31, 60, and 104 ng/g and AUCs of 178, 357, and 566 ng·hr/g at doses of 0.5, 1.0, 1.5 mg/kg, respectively. The Cmaxs and AUCs increased in proportion to the dose, indicating linear pharmacokinetics of mosapride up to 1.5 mg/kg. The pharmacokinetic profiles of mosapride in horses are quite different from that in humans. The average t1/2 in horses was almost 2 fold longer than that reported in healthy adult humans. Therefore, it is thought that it is suitable to reduce the number of doses a day in horses compared to humans.
- 社団法人 日本獣医学会の論文
著者
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SASAKI Naoki
Department of Gynecology and Obstetrics, National Defense Medical College
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Sasaki Naoki
Department Of Applied Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine
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Sasaki Naoki
Clinical And Pathobiology Division Equine Research Institute Japan Racing Association
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Sasaki Naoki
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
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Yamada Haruo
Department Of Clinical Veterinary Science Obihiro University Of Agriculture And Veterinary Medicine
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Yamada Haruo
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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INOKUMA Hisashi
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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OKAMURA Koichi
The United Graduate School of Veterinary Sciences, Gifu University
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FUKUNAKA Morito
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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Inokuma Hisashi
Department Of Applied Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine
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YAMADA Haruo
Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine
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