Becker Muscular Dystrophy-Like Myopathy Regarded as So-Called "Fatty Muscular Dystrophy" in a Pig: A Case Report and Its Diagnostic Method
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概要
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We describe a case of human Becker muscular dystrophy (BMD)-like myopathy that was characterized by the declined stainability of dystrophin at sarcolemma in a pig and the immunostaining for dystrophin on the formalin-fixed, paraffin-embedded (FFPE) tissue. The present case was found in a meat inspection center. The pig looked appeared healthy at the ante-mortem inspection. Muscular abnormalities were detected after carcass dressing as pale, discolored skeletal muscles with prominent fat infiltrations and considered so-called "fatty muscular dystrophy". Microscopic examination revealed following characteristics: diffused fat infiltration into the skeletal muscle and degeneration and regeneration of the remaining skeletal muscle fibers. Any lesions that were suspected of neurogenic atrophy, traumatic muscular degeneration, glycogen storage disease or other porcine muscular disorders were not observed. The immunostaining for dystrophin was conducted and confirmed to be applicable on FFPE porcine muscular tissues and revealed diminished stainability of dystrophin at the sarcolemma in the present case. Based on the histological observations and immunostaining results, the present case was diagnosed with BMD-like myopathy associated with dystrophin abnormality in a pig. Although the genetic properties were not clear, the present BMD-like myopathy implied the occurrence of dystrophinopathy in pigs. To the best of our knowledge, this is the first report of a natural case of myopathy associated with dystrophin abnormalities in a pig.
- 公益社団法人 日本獣医学会の論文
著者
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Furuoka Hidefumi
Department Of Basic Veterinary Medicine Obihiro University Of Agriculture And Veterinary Medicine
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Asai Tetsuo
National Veterinary Assay Lab. Ministry Of Agriculture Forestry And Fisheries Tokyo
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KOBAYASHI Yoshiyasu
Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
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OCHIAI Kazuhiko
Department of Basic Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University
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OCHIAI Mariko
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries
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HORIUCHI Noriyuki
Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine
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AIHARA Naoyuki
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries
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MIZUTANI Hiroshi
Shibaura Meat Sanitary Inspection Station
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KOUSAKA Shinichi
Shibaura Meat Sanitary Inspection Station
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NAGAFUCHI Tsuneyuki
Shibaura Meat Sanitary Inspection Station
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OISHI Koji
National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries
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