D-ペニシラミン療法中にネフロ-ゼ症候群と血清IgA値の著減をきたした全身性強皮症の1症例

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D-Penicillamine has been used with increasing frequency in the management of rheumatoid arthritis (RA) and progressive systemic sclerosis (PSS) . However, its therapeutic usefulness has been limited by a high incidence of a variety of adverse reactions.<BR>A 56 year old woman with PSS received D-Penicillamine (600 mg daily) . She went into remission after D-Penicillamine administration, but nephrotic syndrome appeared after one year and 7 months of D-Penicillamine therapy (total dose 253 gm) .<BR>Renal pathologic findings revealed minimal change lesion in the biopsied specimen. Steroid therapy had a good effect on the nephrotic syndrome. In addition, decreased serum IgA level (26 mg/dl) was observed after one year and 7 months of D-Penicillamine therapy. Serum IgA level reversed 12 months after discontinuation of D-Penicillamine therapy. D-Penicillamine therapy's beneficial effects on management of various side effects weve essentially observable.
学校法人昭和大学・昭和医学会の論文