99mTc-MDP(Methylene diphosphonate)による骨外性集積について

概要

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The 99mTc-phosphates have been used as bone scanning agents. Abnormal extraosseous accumulation of 99mTc-phosphates was noted in 10 cases. The lesions associated with extraosseous accumulation are as follows ; 1 breast cancer, 2 neuroblastomas, 1 Wilms' tumor, 1 Hodgkin's disease, 1 rectum carcinoma, 1 pulmonary fibrosis, 1 abdominal wall metastasis of gastric cancer, 1 operation scar and 1 hepatoblastoma. In other several author's reports of abnormal extraosseous accumulation in malignant tumor, it is suggested that 99mTc-phosphate is concentrated in the region where Ca-P metabolism is accelerated. However, it is known as a fact that positive or negative findings are pointed out even in pathologically same diseases. For interpretation of this mechanism, several opinions have been suggested, but it remains as an unsolved problem.
学校法人昭和大学・昭和医学会の論文