放射性コロイドの取り込みについて-2-肝シンチグラフィ-における肺集積について
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Forty-one cases of RI lung accumulation were selected from 1536 cases among liver scintigraphy of <SUP>99m</SUP>Tc-Sn-colloid. The results of analysis of these cases are as follows:<BR>1) The cases of lung accumulation caused by failure of preparing <SUP>99m</SUP>Tc-Sn-colloid were excluded. The lung accumulation in liver scintigraphy was able to be found only in <SUP>99m</SUP>Tc-Sn-colloid with large sized particle.<BR>2) From several facts, it is not considered that <SUP>99m</SUP>Tc-colloid was taken into the lung in form of macroaggregation after injection.<BR>3) The lung accumulation of <SUP>99m</SUP>Tc-colloid was not always detected in the cases with any liver disorder.<BR>4) The great majority of cases with the lung accumulation were malignant tumor, the next was liver cirrhosis. When the patients were in the most severe condition, <SUP>99m</SUP>Tc-colloid apt to be revealed in the lung. In the cases of children, the marked accumulation of the lung was always observed.<BR>5) The lung accumulation of <SUP>99m</SUP>Tc-Sn-colloid was also observed in many patients with splenomegaly without liver disease. It is not a phenomena from the result of decrease in hepatic blood flow or of portal hypertension, but it may be related with certain immunological chnge.<BR>6) Most patients with the lung accumulation were in extremely severe condition and their survival was not so good. Therefore, this phenomena could refer to a indicator of poor prognosis.<BR>7) The lung accumulation of RI colloid may be revealed when patients fall into extremely severe stage and pulmonary macrophages are stimulated. Its phenomena would be essentially caused by a mechanism that RI-colloid are phagocyted by pulmonary macrophages.
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