点滴静注用Minocyclineの使用経験

概要

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Clinical efficacy of Minocycline (i. v.) in various infectious diseases in the field of otolaryngologics was examined. There were 8 subjects, including 4 cases of otitis media chronica, 2 cases of otitis media acuta with general complication, and cases of malignant tumor with postoperative or non operative infection.There were 6 men and 2 women from 25 to 69 years of age. The administration was intravenous and the dosage was 200mg/day in Lactec G 500ml for 2 to 6 days. Pseudomonas, Proteus, Serratia, Acinetobacter, Staphylococcus aureus were isolated from the patients as causative pathogens and most were sensitive to 3.13μg/ml or less of Minocycline. The efficacy of the treatment with Minocycline was judged on the basis of clinical progress and local or general improvement. The results were excellent in 4 cases, good in 2, and fair in 1. One patient did not return for evaluation. Side effects occurred in one, skin rash inflammation in another and erythema in the third patient.
耳鼻咽喉科臨床学会の論文