耳茸症の病態と薬物療法--塩化リゾチ-ム(ノイチ-ム)の使用治験からの考察

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Lysozyme chloride (Neuzym) was used in 18 patients with nasal polyp at the dose level of 270mg/day for long periods.1. The global assessment of the responses of 18 patients was such that the drug effect was excellent in 22.2% (4 patients), good in 16.7% (3) and fair in 38.8% (7). In short, the rate of effectiveness was 38.8% (7) when the "fair" response was excluded.2. The drug effect was excellent or good in many patients of the groups which received the drug for periods of 21 to 42 days. After 21 to 42 days of treatment, the rate of effectiveness was 33.3% (6 patients) which the "fair" response was excluded.3. The number of patients who showed a response better than "fair" was greatest among those who had a 3-years or shorter length of history of nasal polyp. In this group of patients, the rate of effectiveness was 50.0% (6 of 12 patients) when the "fair" response was excluded.4. The drug effect was better than "fair" when nasal polyps were P1 or smaller in size, whether they were isolated or multiple. In the case of P2 or smaller isolated nasal polyps, the rate of effectiveness was 50.0% (5 of 10 patients) when the "fair" response was not included and 90.0% (9 of 10) when the "fair" response was also taken into account, whereas in the case of multiple nasal polyps the corresponding figures were 40.0% (2 of 5), and 60.0% (3 of 5) respectively. In short, the rate of effectiveness was a little higher with isolated polyps than with multiple ones.5. The drug effect was excellent or good in a relatively larger number of patients without a history of nasal polypectomy.6. No side effects of the drug were elicited, nor were the laboratory data abnormal.
耳鼻咽喉科臨床学会の論文

耳茸症の病態と薬物療法--塩化リゾチ-ム(ノイチ-ム)の使用治験からの考察

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