セロクラ-ル錠(Ifenprodil)のめまい患者に対する二重盲検法による検討

概要

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The therapeutic erects and safety of Ifenprodil on vertigo and dysequilibrium were compared with Diphenidol using a double blind method, on 105 patients in 6 different hospitals. Ifenprodil (20mg×3/day×2 weeks) was given to 52 randomly allocated patients and Diphenidol (50mg×3/day×2 weeks) to 53 patients. Subjective and objective symptoms were checked every week.The following results were obtained.1) Considering the final global improvement rating, Ifenprodil was effective in 76.9% of the patients, while Diphenidol was effective in 62.3% at the 2nd week (non-significant). However, with regard to each symptom, Ifenprodil was superior to Diphenidol.2) As to the results of stratified analysis, Ifenprodil was effective for dysequilibrium (p<0.05), tinnitus (p<0.10) and heavy feeling of the head (p<0.10) due to central vestibular disorders.3) Side effects were observed in 9.6% of the Ifenprodil ingesting group, and 28.3% in the Diphenidol ingesting group (p<0.05).4) In light of these results, Ifenprodil appears to be effective for the treatment of central vertigo.