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Ifenprodil (Cerocral) has been used to improve blood circulation and metabolic activity in the brain. It is well-known that Ifenprodil is effective in cases of circulatory insufficiency of the vertebro-basilar artery. We administered Ifenprodil to 37 patients with vertigo and evaluated its effectiveness on the basis of their subjective symptoms and objective findings.1. The rate of effectiveness was 67% in typical Ménière's disease, 56% in atypical Ménière's disease, 73% in benign paroxysmal positional vertigo and 100% in circulatory insufficiency of the vertebro-basilar artery.2. The frequency of vertiginous attacks was reduced in 73% of the patients, the intensity of verigo in 86%, the equilibrium disturbance in 81%, nausea and vomiting in 88%, heavyhead and headache in 79%, and stiff shoulders in 73%.3. Although many patients had no objective findings, almost all the findings which were noted were reduced.4. There were no side effects of this drug. These results suggest that Ifenprodil is useful in the treatment of vertigo.
耳鼻咽喉科臨床学会の論文