前下小脳動脈血栓によるラット難聴モデル

概要

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We established a new model of hearing disturbance caused by photochemically induced thrombosis in the rat anterior inferior cerebellar artery (AICA). Under pentobarbital anesthesia, the left tympanic bulla and the ipsilateral AICA were ventrally approched. Rose bengal (20 mg/kg) solution was injected intravenously under selective irradiation on the AICA with the focused green light while measuring both compound action potentials (CAP) with the electrocochleogram and cochlear blood flow with laser Doppler flowmetry. The time required to completely occlude the AICA was significantly prolonged by the aspirin pretreatment. And the t-PA successfully reopened the thrombotic occlusion of the AICA followed by complete recovery of the lost CAP. We concluded that this model w as potentially useful for the research on the pathophysiology and the pharmacological therapeutics of the sensorineural hearing disorders due to thrombotic ischemia of the inner ear.
耳鼻咽喉科臨床学会の論文