Clinical Evaluation of Tizanidine Hydrochloride (Ternelin) in the Treatment of Vertigo and Tinnitus.

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The clinical effects of tizanidine hydrochloride on vertigo and tinnitus were investigated in 91 patients (33 males, 58 females).1) The rate of overall improvement of subjective symptoms and objective findings was 74.7% and 74.0%, respectively.2) The rate of improvement of vertiginous symptoms was 90.2% for vertigo and 75.0% for dizziness (non-vertigo), respectively.3) The rate of improvement of tinnitus was 40.5%, higher in those with than in those without stiffness of the neck and shoulders.4) Of the accompanying symptoms, shoulder stiffness was reduced in 72.0%, neck stiffness in 69.8% and headache in 76.7% of the patients.5) The rates of overall improvement and usefulness were 82.5% and 83.6%, respectively.6) Multiple regression analysis showed that the presence of rotatory vertigo, stiffness symptoms and nystagmus significantly contributed to the overall improvement and usefulness score. Therefore we estimated that Ternelin® was more effective in cases of vertigo or tinnitus with stiffness symptoms than in those without these symptoms.7) It is speculated that this drug alleviates vertiginous symptoms by reducing vestibular imbalance through inhibition of γ-motorneuron activity and relieves tinnitus by inhibiting auditory systems through α2-adrenergic receptors.8) The side effects of this drug were observed in 1.9% of 106 patients, but none were severe.