Immunoblastic Lymphadenopathy(免疫芽細胞性リンパ節症)の症例

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Immunoblastic lymphadenopathy is a recently described lymphoproliferative disorder characterized by lymphadenopathy, fever or other constitutional symptoms and evidence of hyperimmunity such as polyclonal hypergammaglobulinemia and pathologically by a non-neoplastic proliferation of immunoblasts, plasma cells and small vessels. The pathogenesis of this clinicopathological syndrome remains obscure.We treated a 35-year-old woman, who complained of a palpable, gradually increasing bilateral cervical lymphnodes over a preceding two months. Polyclonal hyperglobulinemia and lymphopenia were also present. The clinical findings and biopsy specimen of the cervical lymphnode suggested a malignant lymphoma and therapy with 60Co irradiation (1200 rads) was initiated. A complete clinical remission was noted within one week. Thereafter, the pathologic report was reviewed and here the histologic picture was compatible with the diagnosis of immunoblastic lymphadenopathy. The radiation therapy was then discontinued.She remains symptom-free and there is no objective evidence of a recurrence.
耳鼻咽喉科臨床学会の論文