Cholinergic receptors in the nasal blood vessels of the dog.

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It has been established that acetylcholine causes peripheral vasodilatation. Recent studies with in vitro muscle tension detecting devices suggest that, at least in large blood vessels, higher concentrations of the Cholinergic transmitters cause vasoconstriction. Vasodilating responses to acetylcholine are indirect and can be evoked either by decreasing the norepinephrine output from the adrenergic nerve terminal, or by stimulating the endothelial cells to generate yet unknown relaxing agents. In our experiments with in vitro preparations of the vascular smooth muscle of the canine nasal mucosa, the three above-mentioned cholinergic receptors (adrenergic nerve endings, vascular smooth muscle cells, and endothelial structures) were demonstrated. The cholinergic contractions were Ca2+ dependent.
耳鼻咽喉科臨床学会の論文