頭頚部悪性腫瘍患者における好中球遊走能

概要

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Neutrophil chemotaxis in patients with head and neck malignancy was measured with the in vitro agarose plate technique. In 44 patients, chemotactic ability was evaluated both before and three months after treatment. In addition, 13 end-stage patients were examined.The chemotactic index, a ratio of chemotaxis to random migration, in patients with neoplasms was 1.82±0.30 (S. D.), which was significantly less than that of healthy controls (2.01±0.25) [P<0.05]. There was no difference before or after treatment in these patients. However, in regard to the posttreatment condition of the patients without tumor the chemotactic index was significantly more than that of those with residual neoplasia [P<0.05]. Chemotaxis of the end-stage patients was much smaller.These results suggest that chemotactic capability of neutrophils in patients with tumor is decreased, and the more advanced the tumor is, the less the chemotaxis becomes.Random migration of leukocytes was not impaired in patients at any stage.
耳鼻咽喉科臨床学会の論文