Otitis media with effusion and endotoxin.

概要

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It is known that the endotoxin of gram negative bacteria is not only antigenic, but also has many biological activities. In this study, endotoxin in human middle ear effusions (MEE) was measured quantitatively by the chromogenic substrate method which is more sensitive and accurate than Limulus assay.Fifty samples of MEE from 46 patients aged 2 to 84 years were classified into two groups, 24 mucoid and 26 serous. The endotoxin in the mucoid group was significantly higher (264.6pg/ml) than that in the serous group (27.5pg/ml). This suggests that bacterial endotoxin contributes greatly to induce otitis media with mucoid effusion.Audiometry showed that the majority of those with otitis media and mucoid effusion had conductive type deafness, while mixed type deafness was more common in those with serous effusion.
耳鼻咽喉科臨床学会の論文