頭頸部悪性腫瘍に対する血液吸着法を併用した : 一時的動脈閉塞下抗癌剤動注療法

概要

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It is known that transcatheter intraarterial drug delivery presents a higher concentration of drug in the tumors than intravenous administration only. In our field, a transcatheter arterial infusion from superficial temporal artery into tumor site has been commonly used for the treatment of head and neck tumors.Recently, the intraarterial infusion under its temporary occlusion has been employed in the patients with hepatic tumors using double lumen balloon catheter. In this study, it was intended to use not only intraarterial infusion-occlusion system from superficial temporal artery, but also to reduce the systematic side effects of the drugs recirculating from regional area by means of direct hemoperfusion with charcoal filament.The concentration level of anti-cancer drugs in the tissues received infusion-occlusion chemotherapy was significantly high. The hemoperfusion with chacoal filament, to eliminate the drugs in the blood recirculating from regional areas, worked successfully showing significant adsorption within 180 minutes after infusion.We believe that a new system of intraarterial drug delivery by means of balloon occluded arterial with hemoperfusion proposed in the present study will be much effective for chemotherapy of head and neck tumors.